| Objective:To study the correlation between the population levels of serum inflammatory cytokine and the severity of depressive symptoms and cognitive function in patients plagued with depressive disorders and find out possible biomarkers according to symptoms of patients,so as to delve into the clinical significance of monitoring serum cytokines among patients with depressive disorders.Approaches:According to the physical examination center,43 patients who have been in the hospital from July to December 2022 and meet the standards were culled as the case group,while 43 people who are in normal conditions were selected as the control group.In both groups,general data was required to be gathered,we also measure serum cytokine levels,and conduct the Chinese simplified beta version of the Neurocognitive Test(CBCT).In addition,the case group was required to measure the Hamilton depression scale,HAMD-24.All data were collected and entered into SPSS 26.0 and R4.1.3 software for statistical analysis.For quantitative data,the mean and confidence interval or median(interquartile range)were used,while for counting data,frequency(percentage)was used.Comparison between groups was carried out using independent sample t-tests and chi-square tests,and diagnostic prediction analysis wass performed using ROC curves.In addition,Pearson correlation analysis and generalized linear models were used to analyze the correlation between cytokine levels and depressive symptoms and cognitive function.When P<0.05,the difference was statistically significant.The above study has been approved by the Ethics Committee of Linyi Mental Health Center,and all participants and / or their guardians were fully informed.Results:1.There was no significant difference in IL-1β between control group and case group(P>0.05).The expression levels of IL-2,IL-6,IL-8 and IL-10 in the case group were higher than those in the control group,and the difference was statistically significant(P<0.05).2.Depression,suicide,the difficulty falling asleep,work and interest,sense of decrease in work,inferiority complex,and total score were not significantly related to IL-1β,IL-2,IL-6,IL-8,and IL-10(P>0.05).Psychiatric anxiety was not significantly related to IL-1β,IL-2,IL-8,and IL-10(P>0.05),and systemic symptoms were not significantly related to IL-1β,IL-2,IL-6,and IL-10(P>0.05).Psychiatric anxiety was negatively correlated with IL-6(P<0.05),while systemic symptoms were positively correlated with IL-8(P<0.05).3.When the level of IL-2 is more than or equal to 0.95pg/m L,the level of IL-6 is more than or equal to 3.75pg/m L,the level of IL-8 is more than or equal to 13.70pg/m L,and the level of IL-10 is more than or equal to 0.95pg/m L,the efficacy for diagnosis and prediction of disease is optimum.4.Serum cytokines were significantly correlated with each subdivided dimension of cognitive function assessment.Multiple dimensions of cognitive scores and overall cognitive evaluation of patients were significantly affected by serum levels of IL-2 and IL-10.Conclusions:1.High concentration of serum IL-2,IL-6,IL-8 and IL-10 suggest that the occurrence of depression may be involved in immune inflammatory responses.2.The serum level of IL-6 is related to the patient’s psychiatric anxiety,and the serum IL-8 level is associated with the systemic symptoms of the patient.3.IL-1β level has no predictive value for the diagnosis,while IL-2,IL-6,IL-8 and IL-10 level,especially on the condition that IL-2 level is more than or equal to 0.95pg/m L,IL-6level is more than or equal to 3.75pg/m L,IL-8 level is more than or equal to13.70pg/m L,and IL-10 level is more than or equal to 0.95pg/m L,the efficacy for diagnosis and prediction of disease is optimum.4.The serum IL-2 level and IL-10 level are closely related to the pathogenesis of cognitive dysfunction in patients,so it is speculated that it can be used as an effector marker of cognitive dysfunction in patients with depressive episodes and recurrent depressive disorder. |
PDF Full Text Request