| Objective:Explore the peak bone mass in different parts of normal population in Taiyuan area and the age at which peak bone mass occurs,and explore the lifestyle habits that affect the accumulation of bone mass before peak bone mass and the age at which peak bone mass occurs,as well as the influence of previous hyperthyroidism(hyperthyroidism)on peak bone mass.To optimize the lifestyle factors that influence peak bone mass and increase awareness of the skeletal effects of adolescent hyperthyroidism,promote early screening and treatment to reduce the risk of low bone mass or osteoporosis in later life.Methods:A total of 546 healthy people aged 21-40 who had been living in Taiyuan for 5years or more were randomly selected from the physical examination database as the research objects.Males and females were divided into four groups 21-25 years old(27cases of male lumbar spine,24 cases of male hip,23 cases of female lumbar spine,20cases of female hip),26-30 years old(29 cases of male lumbar spine,26 cases of male hip,21 cases of female lumbar spine,30 cases of female hip),31-35 years old(53 cases of male lumbar spine,34 cases of male hip,32 cases of female lumbar spine,female hip group 38 cases in the department)and 36-40 years old(46 cases in the male lumbar spine,56 cases in the male hip,38 cases in the female lumbar spine,49 cases in the female hip)according to the age group of every 5 years.Participants were given detailed questionnaires about height,weight,soda consumption,coffee consumption,alcohol consumption,eating habits,milk and outdoor exercise,BMD of lumbar spine(L1-4),hip including Neck of femur,Troch,Ward’s and Total hip was determined by dual-energy X-ray absorptiometry produced by Hologic.To explore the peak bone mass at different bone parts,the age of peak bone mass and the influence of life habits on peak bone mass of normal population in Taiyuan City.At the same time,88 cases of patients(30 males aged 21-25,30 males aged 26-30,and 28 females aged 31-35)with clear history of hyperthyroidism before the peak age of bone in different parts and currently in the peak age of bone were collected in the outpatient department of our hospital from January2017 to January 2022.General data were collected.BMD values of lumbar spine(L1-4),hip including Neck,Troch,Ward’s and Total hip were determined.All data were analyzed by SPSS 25.0 statistical software.Normality test was conducted for each group of data.Quantitative data consistent with normal distribution were represented by (?)±s.BMD values of lumbar spine(L1-4),Neck,Troch,Ward’s and Total hips were used as dependent variables,and body mass index(kg/m~2),intake of carbonated beverages,coffee,milk,alcohol consumption and outdoor activities were used as independent variables.After single factor regression analysis was used to select statistically significant variables,multi-factor stepwise regression analysis was carried out to estimate the possible role of living habits and other factors.Comparison between the two groups was performed by t test.P<0.05 was considered statistically significant.Results:1.Peak bone mass and age of peak bone mass in different parts of healthy males in Taiyuan area:In Taiyuan area,the PBM of healthy male lumbar spine appeared in the age range of 26～30 years,while the PBM of Neck,Troch,Ward’s and Total appeared in the age range of 21～25 years,and the PBM was L1:(1.022±0.126)g/cm~2,respectively.L2:(1.076±0.159)g/cm~2;L3:(1.089±0.157)g/cm~2;L4:(1.063±0.144)g/cm~2;L1-4:(1.088±0.160)g/cm~2;Neck:(0.923±0.051)g/cm~2;Torch:(0.742±0.166)g/cm~2;Ward’s:(0.870±0.102)g/cm~2;Total:(1.073±0.079)g/cm~2.2.Peak bone mass and age of peak bone mass in different parts of healthy women in Taiyuan area:In Taiyuan area,the PBM in lumbar spine,Neck,Troch,Ward’s and Total appeared in 31～35 years old,and the PBM was L1:(0.999±0.104)g/cm~2,respectively.L2:(1.058±0.143)g/cm~2;L3:(1.085±0.141)g/cm~2;L4:(1.059±0.136)g/cm~2;L1-4:(1.083±0.167)g/cm~2;Neck:(0.830±0.149)g/cm~2;Torch:(0.685±0.109)g/cm~2;Ward’s:(0.732±0.154)g/cm~2;Total:(0.978±0.118)g/cm~2.3.Possible influencing factors of male peak bone mass formation:BMI,milk,outdoor exercise have a great effect on the formation of male lumbar peak bone mass.BMI and milk play a significant role in the formation of peak bone mass in male Neck and Ward.BMI plays a significant role in the formation of peak bone mass of male Troch and Total hip.That is,underweight is not conducive to the formation of peak bone mass in male lumbar spine and hip,adequate milk intake is conducive to the accumulation of peak bone mass in male lumbar spine,Neck and Ward’s,and increasing outdoor exercise is conducive to the accumulation of peak bone mass in male lumbar spine.4.Possible influencing factors of female peak bone mass formation:BMI,milk,carbonated drinks and alcohol consumption have a great effect on the formation of female lumbar peak bone mass.BMI and milk play a significant role in the formation of peak bone mass in Neck and Ward.BMI plays a significant role in the formation of peak Troch bone mass in women.BMI and carbonated beverages had a greater effect on the formation of peak hip mass(Total)in women.That is,underweight is not conducive to the formation of peak bone mass of lumbar spine and hip,adequate milk intake is conducive to the accumulation of peak bone mass of lumbar spine,Neck and Ward,large intake of carbonated beverages is not conducive to the accumulation of peak bone mass of lumbar spine and total hip,and large amount of alcohol is not conducive to the accumulation of peak bone mass of lumbar spine.5.BMD of lumbar spine,neck of femur,trochanter,trigone and total hip in both male and female hyperthyroidism group was significantly lower than that in normal control group(P<0.05),and the difference was statistically significant.Conclusion:1.The age of peak bone peak at different parts of bones in different gender groups was different,and the level of peak bone peak was different.Optimizing the lifestyle factors that affect PBMS is an important strategy for maximizing PBMS in adolescents and young adults,thereby reducing the risk of low bone mass or osteoporosis later in life.2.Hyperthyroidism before peak bone age has an important effect on peak bone mass of adolescents,which can lead to a decrease in peak bone mass;During the treatment of adolescent hyperthyroidism,attention should be paid to monitoring bone density and early intervention to minimize the loss of peak bone mass. |
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