Clinical Study Of Baoyuan And Taohong In Patients With HFrEF Of Qi Deficiency And Blood Stasis

Objective: To determin the clinical efficacy of baoyuan and taohong on patients with HFr EF with qi deficiency and blood stasis.Methods: 70 patients meeting the inclusion criteria were randomly divided into control group(35 cases)and treatment group(35 cases).The control group was given western medicine,and the treatment group was given baoyuan and taohong on this basis.After continuous treatment for 6 weeks,TCM symptom score,single major disease,left ventricular ejection fraction(LVEF),left ventricular diameter and E/A,amino-terminal B-type natriuretic peptide(NT-pro BNP),New York Heart Association(NYHA)cardiac function rating,6-minute walking test(6MWT),and Minnesota Heart Failure Quality of Life Scale(MLHFQ)were analyzed.Results: In this study,35 patients were randomly assigned in the control group and the treatment group respectively.There was no statistical significance in baseline data between the control group and the treatment group(P > 0.05),so the baseline data of the two groups did not affect the final results and the data of the two groups were comparable.1.TCM symptom scores After treatment.the TCM symptom scores of the control group was 74.29%,and that of the treatment group was 85.71%.The difference between the two groups was statistically significant(P < 0.05),and the treatment of the two groups was effective while the combination of baoyuan decoction and taohong decoction and western medicine was more effective.2.Traditional Chinese Medicine Main Symptoms.The symptoms of shortness of breath/wheezing and fatigue were improved in both groups before and after treatment(P <0.05),while the symptoms of palpitation were not improved(P > 0.05).After treatment,the effect of shortness of breath/wheezing and fatigue in the treatment group was better than that in the control group(P < 0.05),but there was no significant difference in the symptoms of palpitation(P > 0.05).Both groups improved symptoms of shortness/wheezing and fatigue,and the treatment group was more effective,but there was no significant improvement in palpitation symptoms.3.LVEF level.The control group did not improve the LVEF level after 6-week treatment(P > 0.05),but the treatment group significantly increased the LVEF level(P < 0.05),and the treatment group was significantly better in improving the LVEF level than the control group.4.Left ventricular diameter,E/A.After 6 weeks of treatment,there was no significant difference between the two groups(P > 0.05),indicating that ventricular remodeling was not reversed in both groups during treatment.5.NT-pro BNP level.After 6 weeks of treatment,there was a statistically significant difference between the two groups(P < 0.01).Both groups could significantly reduce the level of NT-pro BNP,and the treatment group had a better effect,but neither group could restore the level of NT-pro BNP to normal level.6.NYHA Classification.There were statistically significant differences in the control group(P < 0.05)and the treatment group(P < 0.01)before and after treatment,also treatment group after treatment(P < 0.05).The two treatments could improve the cardiac function classification,and the effect of the treatment group was significantly better.7.The result of 6-minute walking test(6MWT).There was a significant difference in the two groups between before and after treatment(P < 0.01),and there was a significant difference between the two groups after treatment(P < 0.05).Both treatment schemes could significantly improve the results of 6MWT,and the treatment group had better performance.8.MLHFQ.After 6 weeks of treatment,there were statistically significant differences in the total score between the two groups(P < 0.01),and statistically significant differences in the physical and emotional profiles between the two groups(P < 0.05),but no statistically significant differences in others(P > 0.05).Both treatment regiments significantly improved the quality of life of patients with heart failure,moreover the treatment group was more effective than the control group in improving both the physical and emotional profiles.Conclusion: Baoyuan and Taohong combined with conventional western medicine were more effective than the control group on improving TCM symptom scores(shortness of breath/wheezing,fatigue),LVEF,NT-pro BNP,NYHA cardiac function grade,6MWT,MLHFQ(physical and emotional fields)of patients with chronic HFr EF of Qi deficiency and blood stasis.No obvious adverse reactions were shown.In sum,baoyuan and taohong had a satisfying effect on patients with HFr EF of qi deficiency and blood stasis.