Study On The Distribution Of Syndromes And Syndrome Elements In Different Pathological Stages Of Chronic Gastritis "inflammation-cancer Transformation" And Their Correlation With H

Object:The patterns of gastric cancer:Normal gastric mucosa-Chronic non-atrophic gastritis-Chronic atrophic gastritis-Intestinal metaplasia/Atypical rights-astric cancer has been widely recognized at home and abroad scholars,delay to gastric cancer,block or reverse the chronic gastritis disease evolution has important clinical significance and social value.At present,for the delay,block or reverse the chronic stomach hot cancer transformation process,there is no effective treatment methods,traditional Chinese medicine has significant advantage in this aspect,but didn’t form a unified specification standard of clinical diagnosis and treatment,is not conducive to clinical syndrome differentiation and the development of syndrome standardization study.In this study,the multi-center,large-sample clinical study was conducted to investigate the correlation between different pathological stages and TCM syndromes and syndrome distribution in the pathogenesis of HP-mediated chronic gastritis,and to summarize the dynamic and continuous changes.Among them,the changes of common syndromes and syndrome elements in HP negative and positive patients are to obtain clinically reliable syndromes and syndrome distribution,improve the accuracy and efficacy of clinical syndrome differentiation,and establish a chronic gastritis "inflammation cancer transformation process" The card lays the foundation for combining the staged and phased syndrome differentiation system.Methods:This paper includes two aspects:theoretical research and clinical research:1.Theoretical research:write a review of two articles.The first article elaborates the understanding and relevant current situation of chronic gastritis cancer,focusing on the development mechanism,prevention and treatment of diseases and the status quo.The second change at different stages in the process of chronic stomach hot carcinoma syndrome and syndrome factor research present situation,the emphasis on chronic gastritis in different stages of the development and the correlation of disease of traditional Chinese medicine,TCM treatment progress.2.In this study,a multi-center,large-sample cross-sectional study method was used to include 747 patients with chronic gastritis“inflammatory cancer transformation" at different pathological stages in the third-grade hospital of Grade A,including 382 chronic non-atrophic gastritis(145 of them).For example,HP is positive),281 cases of chronic atrophic gastritis(134 of which are HP positive),and 84 cases of gastric cancer(42 of which are HP positive),using unsupervised statistical methods for statistical data mining,using principal component analysis combined factor analysis And systematic statistical methods,analysis of HP negative and HP-positive chronic non-atrophic gastritis,chronic atrophic gastritis and gastric cancer patients with syndromes,syndrome distribution,and comprehensive description of chronic gastritis "inflammatory cancer"(chronic The distribution of syndromes and syndromes in different pathological stages during non-atrophic gastritis-chronic atrophic gastritis-gastric cancer.Result:The study was divided into 6 groups,the HP-negative CNAG syndrome type was 6,HP There are 6 syndrome types of positive CNAG.HP negative CAG syndrome type is 5 In order,the stomach yin deficiency syndrome>spleen deficiency dampness syndrome>spleen and stomach deficiency cold syndrome>spleen and stomach dampness syndrome>liver and stomach disharmony syndrome;HP positive CAG syndrome type is 5,followed by liver and stomach disharmony>spleen dampness Distressed syndrome>Spleen and stomach deficiency syndrome>Stomach yin deficiency syndrome>Liver and stomach stagnation syndrome,HP-negative GC syndrome type is 6:spleen deficiency dampness syndrome,spleen and stomach weakness syndrome,liver and stomach stagnation syndrome,liver and stomach disharmony syndrome,spleen and stomach Damp heat syndrome,qi and blood deficiency syndrome;HP positive GC syndrome type is 5:Qi and yin deficiency syndrome,spleen and stomach weakness syndrome,liver and stomach disharmony syndrome,spleen deficiency and dampness syndrome,spleen and stomach dampness syndrome.HP-negative CNAG has 10 disease syndromes:stomach>spleen>heart>biliary>liver>large intestine>small intestine>lung>ki dney>thoracic,HP positive CNAG has 8 disease syndrome:stomach>liver>heart>spleen>large intestine>small intestine>kidney>lung.There were 7 HP-negative CAG disease syndromes:stomach>spleen>large intestine>small intestine>liver>biliary>heart,and HP positive CAG disease syndrome was 9.The HP-negative GC has 6 disease syndromes:spleen,stomach,heart,liver,gallbladder,lung,and HP positive GC has 6 disease syndromes:spleen,stomach,heart,liver,gallbladder,and lung.HP-negative CNAG has 13 disease syndromes.HP positive CNAG disease There are 14 sexual syndrome.HP negative CAG disease syndrome is 12:wet>yin deficiency>tan>qi deficiency>qi stagnation>yang deficiency>heat>impotence>blood deficiency>blood heat>cold>blood cold,HP positive CAG disease syndrome is 12:qi stagnation>qi deficiency>yin deficiency>yang deficiency>wet>impotence>blood deficiency>phlegm>heat>blood sputum>blood heat>food.HP-negative GC has 11 syndromes:qi deficiency,yin deficiency,impotence,blood deficiency,qi stagnation,blood heat,blood stasis,yang deficiency,dampness,heat,and sputum.The pathogenic syndrome of HP-positive GC is 12:blood deficiency,blood stasis,yin deficiency,qi deficiency,yang deficiency,dampness,qi stagnation,impotence,heat,blood heat,food,sputum.Conclussion:In the course of the transformation of chronic gastritis,the distribution of syndromes in different pathological stages is different.contrast CNAG,the CAG,GCsyndrome types can be concluded that,throughout the three stages of spleen deficiency syndromes type cold syndrome and liver stomach doesn’t pass.Factors through three stages of pathology,CNAG stage for "factors,give priority to with real," the CAG stage for "factors,mainly virtual",GC stage for "factors,this virtual reality".The disease is mainly in the stomach,spleen,and liver,involving the heart,bile and other viscera,qi stagnation,wet through the whole process.