Correlation Between Qi Stagnation And Blood Stasis Syndrome Of Osteoporosis And Depression And Anxiety And Analysis Of Influencing Factor

Objective: To explore the correlation between different syndroms and depression and anxiety in patients with blood stasis and Qi-stagnation Osteoporosis(OP).Methods: The subjects of this study were inpatients with OP who met the inclusion and exclusion criteria and were admitted to the Department of Endocrinology and orthopedics of Changsha Hospital of Traditional Chinese Medicine from January 2022 to December 2022,a total of 180 cases.Fill in the general situation questionnaire,improve the TCM syndrome list for TCM syndrome differentiation of patients,and according to the TCM syndrome type of patients,divide the research objects into 5 groups including syndrome of kidney Yang deficiency group,syndrome of kidney Yin deficiency group,syndrome of liver Yin deficiency group,syndrome of spleen Yang deficiency group and no syndrome group.Hamilton depression scale(HAMD)and Hamilton Anxiety Scale(HAMA)were used to conduct psychological assessment of patients and calculate their scores.Bone Mineral Density(BMD)was determined by dual-energy X-ray bone density detector.To compare the correlation between general condition,TCM syndrome type and depression and anxiety.Results: 1.HAMD score of patients was correlated with age,BMD and BMI(P<0.05);HAMA score was correlated with BMD score(P<0.05)and had no significant correlation with age and BMI(P>0.05);2.There were significant differences in HAMD scores between genders and previous fractures.Women had higher HAMD scores than men,and those with previous fractures had higher HAMD scores than those without previous fractures(P<0.05);There were significant differences in HAMA scores between previous fracture conditions,and those with previous fracture had higher HAMA scores than those without previous fracture(P<0.05)).There was no significant difference in HAMA scores between genders(P>0.05).3.Binary Logistic regression analysis indicated that age,female,and previous history of fracture were risk factors for depression,and BMD was a protective factor for depression(P<0.05),BMI was not an independent factor for depression(P>0.05).Previous history of fracture was a risk factor for anxiety(P<0.05),age,BMI,BMD and female were not independent factors affecting the occurrence of anxiety(P>0.05).4.There was statistical significance in HAMD score difference among different TCM syndrome groups(P<0.05).Pair comparison showed that the HAMD score of the kidney-yang deficiency syndrome group was significantly higher than that of the no-concurrent syndrome group,the liver-yin deficiency syndrome group and the kidney-yin deficiency syndrome group,and the HAMD score of the spleen-yang deficiency syndrome group was significantly higher than that of the no-concurrent syndrome group,the liver-yin deficiency syndrome group and the kidney-yin deficiency syndrome group(P<0.05).There was no statistical significance in the comparison between kidney Yang deficiency syndrome group and spleen Yang deficiency syndrome group,the comparison between no concurrent syndrome group and liver Yin deficiency syndrome group,the comparison between no concurrent syndrome group and kidney Yin deficiency syndrome group,and the comparison between liver Yin deficiency syndrome group and kidney Yin deficiency syndrome group(P>0.05).5.There were statistically significant differences in HAMA scores among different TCM co-syndrome groups(P<0.05).The HAMA score of liver-yin deficiency syndrome group was significantly higher than that of spleen-yang deficiency syndrome group and no concurrent syndrome group;the HAMD score of kidney-yin deficiency syndrome group was significantly higher than that of spleen-yang deficiency syndrome group and no concurrent syndrome group;and the HAMA score of kidney-yang deficiency syndrome group was significantly higher than that of no concurrent syndrome group(P<0.05).There was no statistical significance between hepatyin deficiency syndrome group and kidney-yin deficiency syndrome group,hepatyin deficiency syndrome group and kidney-yang deficiency syndrome group,kidney-yin deficiency syndrome group and kidney-yang deficiency syndrome group,kidney-yang deficiency syndrome group and spleen-yang deficiency syndrome group,spleen-yang deficiency syndrome group and no concurrent syndrome group(P>0.05)6.The result of Logistics regression analysis is that in terms of influencing depression,spleen Yang deficiency syndrome is a risk factor for depression(P<0.05),other syndromes were not independent factors(P>0.05).In terms of affecting anxiety,liver Yin deficiency syndrome and kidney Yin deficiency syndrome were the risk factors affecting the occurrence of anxiety(P<0.05),and other syndromes were not independent factors affecting the occurrence of anxiety(P>0.05)).Conclusion: 1.Increasing age,female and previous fracture in OP patients with blood stasis and Qi-stagnation syndrome were risk factors for depression,and increased BMD was protective factor for depression.OP syndrome of blood stasis and qi stagnation combined with spleen-yang deficiency is a risk factor for depression.2.Previous fracture was a risk factor for anxiety in 2 OP patients with blood stasis qi stagnation syndrome;OP syndrome of blood stasis and qi stagnation combined with spleen-yang deficiency is the risk factor of depression.3.TCM syndrome differentiation is significant for judging the occurrence and development of anxiety and depression in OP patients,and can be used clinically.