Clinical Observation On Tiandan Jiangya Prescription In The Treatment Of Hypertension Complicated With Impaired Glucose Regulation And Liver Yang Hyperactivity And Phlegm And Blood Stasis Syndrom

Objective: This study was conducted to evaluate the clinical efficiency and safety of Tian Dan Antihypertensive Formula in the treatment of hypertension combined with impaired glucose regulation in patients with hyperactivity of liver yang and mutual obstruction of phlegm and stagnation,and to provide a basis for clinical promotion.Methods: In this study,60 patients with hypertension with impaired glucose regulation in combination with hyperactivity of liver-yang hyperactivity and phlegm and stagnation,who attended the outpatient clinic of Hunan Provincial Institute of Traditional Chinese Medicine from January 2022 to January 2023,were enrolled and divided into 2 groups according to a randomized numerical grouping table: the control group and the study group,30 patients in each group.The control group was given telmisartan antihypertensive treatment,while the study group was given telmisartan antihypertensive treatment combined with Tian Dan Antihypertensive soup.After 4 weeks of treatment,the clinical efficacy indexes,upper arm blood pressure,fasting blood glucose,2h post-glucose load blood glucose,fasting insulin,insulin resistance index and other related indexes were observed before and after treatment in both groups,and the related scores and efficacy indexes before and after treatment in both groups were compared to evaluate the clinical efficacy of Tian Dan Antihypertensive Formula in treating patients with hypertension combined with impaired glucose regulation of liver-yang hyperactivity and phlegm and stagnation.Resluts:1.The differences in baseline data such as gender,age,disease duration,and BMI between the two groups were not statistically significant(P > 0.05)and were comparable.2.Comparison of the efficacy of Chinese medical evidence: the total effective rate of the treatment group was 80.00%;the total effective rate of the control group was 53.33%,the difference between the two groups was statistically significant(p < 0.05),and the efficacy of the treatment group was better than that of the control group.3.Comparison of TCM evidence points: the difference between the two groups before treatment was not statistically significant(P> 0.05),and the TCM evidence points decreased in both groups after treatment,and the treatment group was better than the control group,and the difference was statistically significant(P<0.05).4.Comparison of blood pressure: The differences in systolic and diastolic blood pressure between the two groups before treatment were not statistically significant(P > 0.05),and the differences in systolic and diastolic blood pressure between the two groups after treatment were lower in the treatment group than in the control group,and the differences between the two groups were statistically significant(P < 0.05),while the differences in blood pressure before and after treatment between the two groups were statistically significant(P < 0.05).5.Comparison of glycated hemoglobin: The comparison of glycated hemoglobin between the two groups before treatment was not statistically significant(P > 0.05).After treatment,the difference in glycated hemoglobin between the two groups was statistically significant(P < 0.05),and the treatment group was better than the control group in reducing glycated hemoglobin,while the intra-group comparison between the two groups showed statistically significant differences between the two groups before and after treatment(P < 0.05).6.Comparison of fasting blood glucose and 2h blood glucose after sugar load:comparison of fasting blood glucose and 2h blood glucose after sugar load before treatment between the two groups was not statistically significant(P > 0.05).After treatment,the difference between the two groups in fasting blood glucose and 2h after sugar load was statistically significant(P < 0.05),and the treatment group was better than the control group in lowering fasting blood glucose and 2h after sugar load,while the intra-group comparison between the two groups showed that the difference between the two groups before and after treatment was statistically significant(P < 0.05).7.Comparison of fasting insulin and insulin resistance index: the differences in fasting insulin and insulin resistance index between the two groups were not statistically significant before treatment(P > 0.05),and the differences in fasting insulin and insulin resistance index between the two groups after treatment were statistically significant(P <0.05),and the treatment group was better than the control group,while the intra-group comparison showed statistically significant differences between the two groups before and after treatment(P < 0.05).Conclusion:1.Tian Dan Antihypertensive Formula is effective in treating hypertension with impaired glucose regulation in combination with hyperactivity of liver and Yang and mutual obstruction of phlegm and stagnation.2.Tian Dan Antihypertensive Formula can better improve the TCM symptoms of hypertension with impaired glucose regulation in patients with hyperactive liver-yang and phlegm-stasis type hypertension,and reduce blood pressure,blood sugar and glycated hemoglobin.3.This formula has good safety and has the value of promotion and application.