Compatibility Study On The Method Of Cleaning Hot And Cooling Blood (Modification Of Rhinoceros Horn And Rehmannia Decoction) To Treat Allergic Purpura

Allergic Purpura is a kind of common ailment and frequently occurring disease, especially often happened to children and juvenile. It is a kind of allergic hemorrhaging disease of blood vessel. It happens when organism has allergy against some particular matters. It could bring extensive inflammation of small blood vessel, and heighten the capabilities of penetrability and brittleness of small artery and blood capillary, causing exudative hemorrhage and oedema. These symptoms mostly can be seen at skin and mucous membrane; however, it also can be found in Gastrointestinal tract, joints and kidney. Common clinical therapy is to use haemostatic, anti-histamine drug, corticoid and immuno-suppressive drugs etc. The disadvantage of it is its high recrudescent rate. While by applying dialectic therapeutics of Chinese traditional medicine, it can acquire satisfying effect. Among all kinds of allergic purpura, the hot blood and its reckless action are the common symptoms. In clinical experiences, doctors often use "Rhinoceros Horn and Rehmannia Decoction" of various dosage as remedy and it gets excellent curative effect. This thesis makes researches on "Rhinoceros Horn and Rehmannia Decoction" by using various experimental methods such as anti-inflammation, anti-allergy experiments etc. The results reveal that after adding the herb soup to each compatibility group, it could, at different extent, restrain the ear tumefaction of the small rats caused by dimethylbenzene, and the foot tumefaction of the big rats caused by egg white, and the ear tumefaction of guinea pig caused by DMSO. Moreover, it has restraining roles in different level against passive derma allergy of small rats caused by trichosanthini. it could play the obvious restraining role to the dye effusion out ofabdomen of small rat caused by acetum. And it can restrain and counteract the symptoms of derma itch of guinea pig and the tightening up of smooth muscle caused by allergic medium histamine. Also it can counteract the slow-reactants. Furthermore, And it could restrain the casting granules of hypertrophying cells and protect cell membrane. The group of modification of Rhinoceros Horn and Rehmannia Decoction is better than the other groups.Knowing from this, each compatibility group of modification of Rhinoceros Horn and Rehmannia Decoction has the pharmacological effects such as anti-inflammation, anti-allergy and it can be used as antipruritic as well. The mechanism of curing allergic purpura is to contradict against the allergic medium such as histamine and slow-reactant etc and to stabilize the swelling cell membrane and to restrain the casting of the granule Thereby, it could reach the goal of anti-allergy. All in all, it provides the experimental foundation for the clinical therapy to allergic purpura.