The Expression And Role Of 14-3-3 Protein In Human

Gliomas are the most frequent brain tumors and are among the most aggressive of all human malignancies. It accounts for about 50%~60% of human brain tumor in adults. Even with best conventional therapy, the prognosis is dismal. The mean survival time after surgical intervention is within one year in glioblastoma multiformes which is the most malignany in glioma. Glioma development occurs by means of a series of dynamic changes in the genome that confer growth advantages to transformed cells. Among them, suppression of apoptosis is a common phenomenon. By extending the lifespan of abnormal cells, accumulation of transforming mutations can occur, thereby promoting development of the malignant phenotype and resistance to conventional cytotoxic agents. Therefore, further understanding the mechanism of how glioma cells evading apoptosis is crucial for designing new ways to restoration of apoptotic pathways in gliomas.The term 14-3-3 refers to a family of highly conserved, small, acidic dimeric proteins of 28-33 kDa. They received their name in 1967 during a systematic classification of brain proteins that was based on their fraction number on anion-exchange chromatography and migration position in gel electrophoresis. Proteins of this family have been found in all eukaryotic organisms studied so far.