Brain Refreshing Capsule To Improve The Effects And Mechanisms Of Senile Dementia, Memory Loss

Objective:To evaluate the efficacy, and understand the functions and mechanism, of Cerevigora capsule in remedying the memory decline of senile dementia through the pharmacology study, to provide a scientific ground in clinical applications.Methods:1. Utilize chemicals of scopolamine, sodium nitrite, and ethanol to block the three stages of memory, acquiry, consolidation, and reproduction, over naturally aging mice to build the animal model of memory decline (simulating model of senile dementia); then observe the influences of chemicals on the full spectrum of memory with jumping pad experiment and the influences of chemicals on the ischemia and anoxia of encephalon with decollation experiment to evaluate the efficacy of the formula.2. Perfuse senile and young mice with high and low dosages of Cerevigora capsule then observe the content of acetyl cholinesterase (AchE), nerve growth factor (NGF), single amic neurotransmitter (norepinephrine NE, dopamine DA, 5-hydroxytryptamine 5-HT), superoxide dismutase (SOD), and nitric oxide (NO) in encephalon to understand the functions and mechanism of the formula.Results:1. Cerevigora capsule improves the intellectual index of the naturally aging mice of memory decline model.The damages induced by medicals toward all three stages of memory, acquiry, consolidation, and reproduction, can be counteracted by Cerevigora capsule and remedied the memory decline; Cerevigora capsule perfusion to senile mice can prolong the mouth breathing time after decollation; Cerevigora capsule is capable of defending ischemia and anoxia of encephalon, protecting and strengthening brain functions, preventing and remeding the memory decline.2. The functions and mechanism of Cerevigora capsule may speak for the potency of relieving symptoms by dissipating phlegm and revealing the aperture of mind, promoting blood circulation and dissolving stasis.Cerevigora capsule can strengthen the functions of stperoxide dismutase (SOD) and the activities of nitric oxide (NO), the cell informatory agent, increase the clearing rate of norepinephrine (NE) , and alleviate the formation of manondial dehyde (MDA) . This suggest that Cerevigora capsule is potent of defending ischemia and anoxia of encephalon, purging free radicals to prevent the initiation of apoptosis, and preventing and remeding the memory decline. This functions and mechanism may speak for the potency of thi s medicine for relieving symptoms by dissipating phlegm and revealing the aperture of mind, promoting blood circulation and dissolving stasis.3. The functions and mechanism of Cerevigora capsule may speak for the potency of achieving overall wellness by the fortification of kidney and nourishment of bone marrow, and abating the aging processes.Cerevigora capsule has statistical significance in promoting the activities of acetyl chol inesterase (AchE) in the encephalon of senile mice, reinforcing nerve growth factor (NFG) in the hippocampus of rats, and strengthening the capacity of single amic neurotransmitter dopamine (DA). This suggest that Cerevigora capsule is capable of promoting the viability, development and differentiation of neuron, nourishing cholinergic neuron, preventing neuron from damages and prolonging the viability, so that it is capable of abating the aging processes, preventing and remeding the memory decline. This functions and mechanism may speak for the potency of this medicine for achieving overall wellness by the fortification of kidney and nourishment of bone mari'ow, and abating the aging processes.