Sugar Pain Treatment Of Early Diabetic Arterial Occlusive Disease Clinical Research

Part 1 is the literature research of Western Medicine and Traditional Chinese Medicine (TCM) about diabetic arterial obstruction (DAO), involving the related treatment pathway using Traditional Chinese Medicine, the disease name in western medicine, diagnosis, pathological mechanism.Part 2 is the summary, including the scholastic attainment of Professor Chenshuchang in DAO and clinical experiences of diagnosing and treating diabetes as well as complications by Professor Linlan.Part 3 is clinical study: the clinical study of treatment about the early stage of DAO of TangtongfangObjective: To summary the clinical experiences of Professor Linlan, the compound Chinese Medicine Tangtongfang(TTF), on the treatment of DAO, and explore the effect mechanism of TTF.Methods: A random controlled clinical research of 60 DAO patients was operated, the clinical symptom and parameters were observed, including FBS,PBS,PLT, FIB, 24hUGQ, 24hUJPQ, HbAlc, ALD, AngL AngII, ET-1, TXB2, 6-keto-PGF1a, TG, CHO, LDL, HDL,ABI, blood dynamics. The results were treated statistically.Results: 1 TTF group reaches the marked efficiency as high as 46.6%, the general effective rate 83.3%; whereas in the Inostoti Nicotinas.group the marked efficiency rate is 26.7% only, and general effective rate 60%. Ridit analysis gives the result of P<0.05, with significant difference. 2 P>0.05 was showed of both groups with comparison of parameters as FBS, PBS, HbA1c , PLT, FIB, TG, LDL, HDL, PL RL internal diameter variation of artery; however other parameters show the result of P<0.05, including 24hUGQ, 24hUPQ, CHO, TXB2, 6-k-PGF,a, ET-1, ALD, AngI, Angll, ABI, arterial blood flow rate. Tangtongfang superior to that of the group treated with Inostoti Nicotinas.Conclusion: 1. TTF shows marked efficiency in the treatment about the early stage of DAO with the syndrome of Qiyin Deficiency and channels stasis. The general effective rate is 83.3%, a result superior to that of the group treated with Inostoti Nicotinas (general effective rate 60%) . 2 The efficacious mechanism of TTF may be to decrease blood lipid level, dissolve fibrinogen, then improve the blood viscidity and speed the blood flow; to repair damaged endothelial cells, decrease the secretion of ET, ALD, AngI, AngII, and regulate the balance between thromboxane and PGI2, then to repress the coagulation ofplatelet, enlarge blood vessels, renew the flexibility of vessels, increase the blood perfusion, and then reach the treatment result of ameliorating circulation of lower limbs.