Study On The Processing Principle Of Phellodendron

CORTEX PHELLODENDRI CHINENSIS is the dry bark of Phellodendron chinense Schneid., is called"chuan Huangbai".It is commonly used as Chinese material medical .It is bitter and cold , is one of the most commonly used medicine.It is used crudely or after processing.The most active component in the dried bark of the Phellodendron chinense Schneid. is alkaloid,mainly including berberine,magnoflorine,jatrorrhizine,palmatine etc..It is also contained limonin,obacunone,dictamnolide,obacunomic acid etc..The author of this dissertation studied the processing aim of the dried bark of the Phellodendron chinense Schneid.of the traditional and modern literature, processing technology, the quality standard, and the change of chemicals and pharmacology activities after processing. This research explored the processing principle of the dried bark of the Phellodendron chinense Schneid.. there is some direct meanings for the standardization of the processing technique and clinic use and the establishment of the quality standard.The author summed up some processing methods and aims by studying literature and compared all kinds of processing methods in order to establish the reasonable processing method.Firstly this text put the variety of chemistry composition in the comparition of the dried bark of the Phellodendron chinense Schneid. and the processing products. Comfirmed that the main chemistry composition——Berberine,is partly changed to Berberrubine . And the conversion of condition and regulation is studied of the Berberine itself and in the medicinal materials .The result showed that Berberine can changed to Berberrubine when heated 20 minutes at 130℃.The content of Berberrubine go up with the temperature and the time of extension, but later it gradually descend . But in the medicinal materials the conversion condition of Berberine need high terperation and long heating time because the protection function of the cell wall and various chemistry composition that contained in the medicinal materials .In the research of processing technique of the dried bark of the Phellodendron chinense Schneid., firstly the author seeking about the effective factors of processing,later the adopts the L9(34) experiment, taking the content of Berberine and Berberrubine as the indicators to carry on the comprehensive grade point. The best fried technique with salt of the dried bark of the Phellodendron chinense Schneid.is that: 1 hour in bored, frying 6 min at the temperature of 150～160℃, per 100 kg dried bark uses the salt 4 kg,solved by 30% of water of the medicinal materials. The author enlarged the experiment and the result indicated that the processing technique are reasonable and can be carried on.Through the comparision of the microscope ,TLC and HPLC of the Phellodendron chinense Schneid. and Phellodendron amurense Rupr.,the results showed that the quantity of Berberine in the Phellodendron chinense Schneid. is far high than that in the Phellodendron amurense Rupr.,but the quantity of palmatine in the Phellodendron amurense Rupr. is higher than that in the Phellodendron chinense Schneid..The author suggest that should strengthens the pharmacology efficacy of both medicine in order to better with better serve for the clinic.This dissertation completed the study of the quantity standard of the dried bark of the Phellodendron chinense Schneid., the salt-fried of the dried bark of the Phellodendron chinense Schneid. and drafting the elucidation. Establish the method in the content determined of Berberine and Berberrubine.And carried on to show minute details to discriminate also, the thin layer chromatography discrimination, the percent of humidity, ash, remain agrochemicals, measurements such as heavy metals and harmful chemical element etc.This dissertation studide the effects of mice and rats'gastrointestinal function on Phellodendron chinense Schneid. and its different processed products. The traditional processing theories think that the bark is bitter and cold,but after processing ,the characters can be lightened. On the way of gastrointestinal movement and function,the mice weight in the Phellodendron sets gained slowed , the stomach and intestines propulsion rate descend, secreting to compare to the stomach liquid of the big rat to affect greatly, can restrain gastric juice secretion,increase pH of gastric juice , obviously decrease acidity and and gastric acid secretion as well as the activityof pepsin.But the wine group and honey group had no obviously influnce on the account of gastric juice of rats.It can be concluded that Berberine is the substance base of bitter and cold.On the test on multiply the Yin deficiency function,it is indicate that the dried bark of the Phellodendron chinense Schneid. and its various processing products have the obvious action of reinforcing the body liquid,especially the salt processed products.On the test of anti-gout, the dried bark of the Phellodendron chinense Schneid.and its various processing products have the obvious action of anti- gout, but the processing sets with salt have no significantly difference compared with other processing products.