| Phellodendron chinense Schneid with the medical history of more than two thousand years.Phellodendron chinense Schneid bitter and cold,it is usually used to clear heat,dry dampness,purge fire for removing toxin.After the processed with salt is introduced into the kidney,it can alleviate its bitterness,so it is of great significance to explore the Salt-Phellodendron chinense Schneid.Supported by Standardization construction of four traditional Chinese medicine decoction pieces such as Cyathula offinalis Kuan and its Pieces(ZYBZH-Y-S-41)in State Chinese Medicine Administration Bureau,we have formulated the relevant quality standards and processing technical specifications.OBJECTIVEAt the same time,the appearance traits and intrinsic quality indexes were studied.The pieces were evaluated from the inside to the outside to form a comprehensive scientific quality standard.By the time,research on the processing technology,and establish the scientific and excellent processing technical,the quality of cortex phellodendri can be better control-ed,Make full use of the resources of Phellodendron chinense,standardize the technology of Phellodendron chinense and ensure the quality and clinical efficacy of Phellodendron chinense.METHODS1 Applying HLPC,according to the 2015 edition of the Chinese Pharmacopoeia content determination method to optimize the multi-indicator quality control method for simultaneous determination of two alkaloids in the Salt-Phellodendron Chinese Schneid.At the same time,the identification method of Salt-Phellodendron Chinese Schneid fingerprint was established,and 8 of them were identified.The similarity of59 batches of samples was calculated by using the 2002 version of Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System.Qualitative and quantitative analysis of different processing techniques,different salt and cork commodity specifications grade quality,in order to further standardize the Phellodendron salt sputum process,optimize the use of salt and phloem tablets toensure good clinical results.2 According to the 2015 edition of the Chinese Pharmacopoeia,the physicochemical properties of the 59 salt Phellodendron pieces were measured,including(thickness,moisture,ash,alcohol-soluble extracts,impurities,sulfur dioxide,heavy metals,pesticide residues),in which the thickness of the pieces and the alcohol-soluble leaching As one of the indicators of different grades,the remaining physical and chemical indicators shall not be lower than the relevant provisions of the2015 edition of the Chinese Pharmacopoeia.3 Identification The salt phellodendron tablets are characterized by appearance,microscopic and thin layer identification,and can distinguish the salt phoenix by relevant identification information.4 According to the 2016 edition of the National Standard for Edible Salts(GB5461-2016),the determination of the physical and chemical properties of salt is mainly determined by: particle size,whiteness,moisture content,water insoluble matter,water-soluble impurities,sodium chloride content.Iodine ion content,lead ion limit,arsenic ion limit,strontium ion limit,potassium ferrocyanide limit in 11 aspects,the salt was firstly selected,and the best salt huangbai processing technology was screened by single factor and orthogonal design.5 Determination of NaCL content in Sabina chinensis by chloride ion selective electrode method,and control the quality of Salt-Phellodendron Chinese Schneid.RESULTS1 Established a grade evaluation standard for the qualitative and quantitative determination of salt-Phellodendron chinense Schneid,from the appearance of traits to the identification of general physical and chemical properties,as well as the analysis of intrinsic chemical quality in the study of heavy metals in agricultural residues,from the outside to the inside,from the table and the inside,comprehensive analysis of appearance traits and The relationship between intrinsic quality has established a scientific and comprehensive evaluation standard.2 Established a scientific,stable and highly operational salt-Phellodendron chinense Schneid processing technical specification.Based on the initial evaluationcriteria of salt-Phellodendron chinense Schneid grades,the initial selection of salts and the selection of infiltration solvents and the establishment of infiltration time were investigated to determine the temperature and time of processing.Large production verification shows that the preferred processing process is stable and feasible.ConclusionThis experiment comprehensively uses multi-index qualitative and quantitative control methods and multi-factors and multi-levels to comprehensively control the salt-Phellodendron chinense Schneid processing technology.After verification,the method is scientific and accurate,and the processing technology is stable and feasible.It can be used for quality control of salt-Phellodendron chinense Schneid. |
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