| Research purposeIn recent years,research on the treatment of ovulatory infertility have gradually increased.Through the collection of clinical research literature published in recent 20 years of traditional Chinese medicine treatment of ovulatory infertility,systematically evaluate the clinical efficacy of traditional Chinese medicine in the treatment of ovulatory infertility,hoping to find out the current chinese medicine treatment of ovulation disorders.The deficiency and advantages of clinical research in ovulatory infertility provide a reference for future clinical research.MethodsDevelop search strategies,consult the database on the clinical research literature on infertility of ovulation dysfunction in Chinese medicine,Develop exclusion and inclusion criteria,use computerized literature to search the clinical research literature of Chinese medicine treatment of ovulation dysfunction infertility for summarize and analysis.1.Systematic review According to the inclusion criteria and exclusion criteria of the literature,the literature was screened and Jadad score was used.The statistical software ReviewManager5.2 was used to compare the efficacy of META analysis.The ovulation rate and pregnancy rate of ovulation-disordered infertility were compared between traditional Chinese medicine and western medicine.2.Evaluation on the rules of symdrome in TCM of ovulatory disordered infertility and the rules of the use of Chinese Medicinal herbs of ovulatory disordered infertility and the rules of the use of acupuncture points of ovulatory disordered infertility.The literature that meets the inclusion criteria is statistically analyzed.The database is mainly built using Excel software,and descriptive statistics are used.The frequency and percentage are used as statistical methods.Results1.Meta analysisIn this study,3908 studies were retrieved and systematically evaluated.The Jadad scale method was used to evaluate the scores,including 120 studies.The overall quality score was low.There are only 14 high-quality studies.Only 9 study was described as using allocation concealment method.Only 7 study was described as blind.Only a few studies reported follow-up and adverse reactions.Only 28%of the total studies reported follow-up.Only 24%of the total studies reported adverse reactions.Currently,there are various treatments for anovulatory infertility.Meta analysis compares multiple treatments.Comparative analysis of different Chinese medicine treatment methods and western medicine.Cycle Therapy of Chinese medicine,Syndrome Differentiation of Chinese medicine,acupuncture,Acupuncture and Moxibustion therapy,Acupuncture plus Chinese medicine therapy,Acupuncture and Moxibustion plus Chinese medicine therapy,Medicinal moxibustion therapy,Chinese medicine plus moxibustion therapy.Comparative analysis of different traditional Chinese medicine preparations and western medicine,such as Chinese medicine decoction,Chinese patent medicine.Comparative analysis of treatments with different chinese medicine inclusion criteria and Western medicine.Comparison of the same treatments with the same syndrome type of TCM and the same treatment with WHO classification.(1)Cycle Therapy of Chinese medicine Therapy versus Western medicine.The pregnancy rate of Cycle Therapy of Chinese medicine compared with Western medicine is much higher than that of Western medicine group.The ovulation rate of Cycle Therapy of Chinese medicine compared with Western medicine is much higher than that of Western medicine group.(2)Traditional Chinese medicine syndrome differentiation Therapy versus Western medicine.The pregnancy rate of traditional Chinese medicine syndrome differentiation compared with western medicine is much higher than that of western medicine group.There is no significant difference in ovulation rate between traditional Chinese medicine syndrome differentiation and Western medicine.(3)The pregnancy rate of Chinese medicine decoction group compared with western medicine was much higher than that of western medicine group.There was no significant difference in ovulation rate between Chinese medicine decoction group and western medicine.(4)Acupuncture therapy versus western medicine.The pregnancy rate of acupuncture therapy compared with western medicine was higher than that of western medicine group.There was no significant difference in ovulation rate between acupuncture and western medicine.(5)Combined Acupuncture and Moxibustion therapy versus western medicine.The pregnancy rate of combined Acupuncture and Moxibustion therapy compared with western medicine was higher than that of western medicine group.There was no significant difference in ovulation rate between combined Acupuncture and Moxibustion therapy and western medicine.(6)Combined Acupuncture and Chinese medicine therapy versus western medicine.The pregnancy rate of Combined Acupuncture and Chinese medicine therapy compared with western medicine was higher than that of western medicine group.There was no significant difference in ovulation rate between Combined Acupuncture and Chinese medicine therapy and western medicine.(7)Combined Acupuncture and Moxibustion plus Chinese medicine therapy versus western medicine.The pregnancy rate of combined Acupuncture and Moxibustion plus Chinese medicine therapy compared with western medicine was higher than that of western medicine group.There was no significant difference in ovulation rate between combined Acupuncture and Moxibustion plus Chinese medicine therapy and western medicine.(8)Medicinal moxibustion therapy versus western medicine.The pregnancy rate of Medicinal moxibustion therapy compared with western medicine was higher than that of western medicine group.There was no significant difference in ovulation rate between Medicinal moxibustion therapy and western medicine.(9)Chinese medicine plus moxibustion therapy versus western medicine.The pregnancy rate of Chinese medicine plus moxibustion therapy compared with western medicine was higher than that of western medicine group.(10)Comparative analysis of treatments with different chinese medicine inclusion criteria and Western medicine.The pregnancy rate of kidney deficiency type Chinese medicine group compared with western medicine was much higher than that of western medicine group.There was no significant difference in ovulation rate between the kidney-deficiency Chinese medicine group and western medicine.The pregnancy rate of kidney deficiency type Chinese medicine and acupuncture group compared with western medicine was much higher than that of western medicine group.There was no significant difference in ovulation rate between the kidney-deficiency Chinese medicine and acupuncture group and western medicine.The pregnancy rate of kidney deficiency and blood stasis type Chinese medicine group compared with western medicine was much higher than that of western medicine group.There was no significant difference in ovulation rate between the kidney deficiency and blood stasis type Chinese medicine group and western medicine.The pregnancy rate of kidney-deficiency liver-stagnation type Chinese medicine group compared with western medicine group was higher than that of western medicine group.There was no significant difference in ovulation rate between the kidney-deficiency liver-stagnation type Chinese medicine group and western medicine.(11)Comparison of the same treatments with the same syndrome type of TCM and the same treatment with WHO classification.According to the WHO type II classification,the pregnancy rate of Chinese medicine group compared with western medicine was higher than that of western medicine group.According to the WHO II type classification,there were no significant difference in ovulation rate between the chinese medicine group and western medicine.According to the WHO type II PCOS,the pregnancy rate of Chinese medicine group compared with western medicine was higher than that of western medicine group.According to the ovulation rate of the Chinese medicine group and the western medicine in the WHO type II PCOS classification,there were no significant difference in ovulation rate between the chinese medicine group and western medicine.The results showed that when treating ovulatory infertility,the ovulation rate of western medicine is not significant when using acupuncture,traditional Chinese medicine,acupuncture combined with medicine,Chinese medicine moxibustion,acupuncture plus moxibustion and Chinese medicine,the ovulation rate is not significant differences.However,combined with Cycle Therapy of Chinese medicine and traditional chinese medicine syndrome differentiation,there was a significant difference in ovulation rate.It is suggested that Cycle Therapy of Chinese medicine and traditional chinese medicine syndrome differentiation have advantages in promoting ovulation.In summary,the results showed that acupuncture therapy,acupuncture and moxibustion therapy,acupuncture plus Chinese medicine therapy,acupuncture and moxibustion plus Chinese medicine therapy,medicine moxibustion,Chinese medicine plus moxibustion therapy,Cycle Therapy of Chinese medicine therapy,traditional Chinese medicine syndrome differentiation therapy for ovulation disorders infertility pregnancy rate Higher than Western Medicine Group.2.Evaluation on the rules of symdrome and treatment in TCM of ovulatory disordered infertility.There are 57 studies in the Single Prescription of Chinses Medinice therapy treatment.There are 32 studies on acupuncture related therapy treatment.There are 22 studies on moxibustion related therapies treatment.Regarding the rule of treatment,in Chinese Medicine herbs treatment,Single Prescription of Chinese Medicine come frist,Cycle Therapy of Chinese medicine and syndrome differentiation of Chinese medicine come after.Regarding the rule of treatment,Chinese Medicine herbs treatment is the most popular way among all Chinese Medicine treatment medthods for treating ovulatory disorder infertility,followed by acupuncture,and then moxibustion.In Chinese Medicine herbs treatment,Single Prescription of Chinese Medicine come frist,Cycle Therapy of Chinese medicine and syndrome differentiation of Chinese medicine come after.3.Regarding the rule of use of Chinese Medicine herbs.Summarize the results of the frequency analysis,the first 21 most popular Chinese medicine herbs for the treatment of ovulatory disorder infertility are:Cuscuta chinensis Lam,Angelica sinensis,Rehmannia glutinosa,wolfberries,Paeonia lactiflora,Barrenwort,Fructus Ligustri Lucidi,Cyperus rotundus,Salvia miltiorrhiza,chinese yam,Cornus officinalis,Ligusticum chuanxiong,Himalayan Teasel Root,Paeoniae Radix Rubra,Astragalus,Morinda officinalis,Pori a,Rubus idaeus,Suberect Spatholobus Stem,Fluoritum,Bupleuri Radix,Licorice,Persicae Semen,Carthamus tinctoriusetc.The most popular meridian are liver meridian,kidney meridian came after,then spleen meridian,heart meridian,lung meridian,xinbao meridian,gallbladder meridian,large intestine meridian,stomach meridian.The four properties and five flavors commonly used in the treatment of in ovulatory disorder infertility are mainly warm(13),flat(5),and slightly cold(4);five flavors is mainly sweet(18)and bitter(9)Second,spicy(9)again,sour(3)is the end.4.Regarding the rule of use of acupuncture points.There were 32 studies on combined acupuncture and Moxibustion or combined acupuncture and Chinese Medicine with western medicine.The most popular meridian are Renmai,stomach meridian came after,then spleen meridian,bladder meridian,liver meridian,Dumai,kidney meridian,large intestine meridian,xinbao meridian,gallbladder meridian,lung meridian.The 10 most frequently used acupoints are Guanyuan(28),uterus(26),Sanyinjiao(26),Zusanli(21),Zhongji(20),blood Hai(14),Shenshu points(12),Qihai(11)and Taichong points(10),Fenglong points(9).The total frequency of abdomen acupoints in the top ten acupoints was(85),and the total frequency of distal acupoints was(92).The above data suggest that acupuncture treats ovulatory infertility with distal acupoints.5.Regarding the rule of use of Moxibustion points.There are 22 studies on moxibustion or in Chinese medicine combined with moxibustion and western medicine.The most popular meridian are Renmai,Dumai and spleen meridian came after,then stomach meridian,kidney meridian,bladder meridian.The 10 most frequently used acupoints are Shenque(10),Sanyinjiao(6),Guanyuan(6),Zusanli(3),Baihui(3),uterus(3),and Qihai(2),Yaoyangguan(2),Zhongji(2),Ovarian(1).The total frequency of abdomen acupoints in the top ten acupoints was(24),and the total frequency of distal acupoints was(14).The above data suggest that Moxibustion treats ovulatory infertility with abdomen acupoints.ConclusionMETA analysis of TCM clinical research literature for nearly 20 years,The ovulation rate of western medicine is not significant when using acupuncture,traditional Chinese medicine,acupuncture combined with medicine,Chinese medicine moxibustion,acupuncture plus moxibustion and Chinese medicine,the ovulation rate is not significant differences.However,combined with Cycle Therapy of Chinese medicine and traditional Chinese medicine syndrome differentiation,there was a significant difference in ovulation rate.It is suggested that Cycle Therapy of Chinese medicine and traditional Chinese medicine syndrome differentiation have advantages in promoting ovulation.The results showed that acupuncture therapy,acupuncture and moxibustion therapy,acupuncture plus Chinese medicine therapy,acupuncture and moxibustion plus Chinese medicine therapy,medicine moxibustion,Chinese medicine plus moxibustion therapy,Cycle Therapy of Chinese medicine therapy,traditional Chinese medicine syndrome differentiation therapy for ovulation disorders infertility pregnancy rate higher than Western Medicine Group.Regarding the rule of use of Chinese Medicine herbs.The high-frequency used traditional Chinese medicines are Cuscuta chinensis Lam,Angelica sinensis,Rehmannia glutinosa,wolfberries,Paeonia lactiflora,Barrenwort,Fructus Ligustri Lucidi,Cyperus rotundus,Salvia miltiorrhiza,chinese yam.The four properties and five flavors commonly used in the treatment of in ovulatory disorder infertility are mainly sweet and warm.The most popular meridian are liver meridian and kidney meridian.Regarding the rule of use of Acupuncture and Moxibustion points.It is recommended to use Renmai,spleen meridian and stomach meridian.The above data suggest that Acupuncture and Moxibustion treats ovulatory infertility with abdomen acupoints.The external acupoint-uterine acupoint is used as a clinical guidance point. |
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