| Objective: The aim of this study was to evaluate the levels of bone turnover markers(BTMs),including serum N-terminal procollagen of type I collagen(P1NP),beta C-terminal cross-linked of type I collagen(β-CTX),25-hydroxyvitamin D [25(OH)D] and parathyroid hormone(PTH),in healthy Chinese postmenopausal women in the Shanghai suburban district.The study also investigated potential relationships between these markers and bone mineral density(BMD)and the prevalence of osteopenia and osteoporosis in this area.Methods: A population of 4822 postmenopausal women with roots in the community and aged 55-69(62.22±6.75)years old from the suburban district of Nicheng Town in Lingang New City of the Pudong New District in Shanghai,China,was recruited voluntarily by issuing leaflets in local communities.BMD was measured at the lumbar spine,femoral neck,total hip and trochanter using dual-energy X-ray absorptiometry with a Hologic Discovery scanner;2251 women in this group had the serum bone turnover markers25(OH)D and PTH tested with a Roche electro-chemiluminescence system.Results: The prevalence of osteopenia and osteoporosis was 46.62%(2248/4822)and 25.03%(1207/4822),respectively,at the lumbar spine,where BMDs were significantly higher compared with women in the Shanghai downtown area(P<0.001).The median(interquartile range)values of serum P1 NP,β-CTX,25(OH)D and PTH were 59.3(44.7-75.5)ng/m L,370(280-490)ng/L,23.0(17.1-30.5)ng/m L and 31.4(24.9-39.7)pg/m L,respectively.The 25(OH)D levels in postmenopausal women in the Shanghai suburban district were normal rather than insufficient.Serum P1 NP and β-CTX levels presented significantly negative correlations with BMDs at the lumbar spine,femoral neck and total hip(Betastd =-0.098 to-0.208,respectively,P<0.001),whereas PTH levels were negatively correlated with BMDs of the femoral neck and total hip(Betastd =-0.062and-0.054,P<0.01,respectively).No positive associations were found between serum 25(OH)D and BMDs at any site except for the total hip(Betastd =0.051,P<0.01).Conclusions: The BMD of postmenopausal women in the Shanghai suburban district is higher than that in downtown area,and over 60% of the participants had their serum 25(OH)D level over 20 ng/m L.BTMs were negatively correlated with BMDs,suggesting that BTMs are reliable factors for early declines in BMD.Objective: Osteoporotic fracture is the most severe complication of osteoporosis and the thoracic and lumbar vertebrae suffer the highest risk.Vertebrae play an important role in supporting trunk or body movement and protecting the internal organs or spinal cord.The aim of the study was to evaluate the prevalence of vertebral fracture,distribution of prevalent fractures as well the grade of the fractures in community-dwelling elderly in Shanghai downtown area and the early preventing of the vertebral fracture may improve the life quality and lengthening life expectancy in Shanghai community-dwelling elderly.Methods: A population of 14075 Shanghai elderly over 50 years old from six communities including 6313 male(aged 60-97yr)and 7762female(aged 60-98yr)was gathered voluntarily through chester sampling from Jul.2014 to Oct.2016.All participants took x-ray plain film of lateral thoracic and lumbar spine by Rontgen unit in community health centre and the films were read by an experienced radiography observer in Shanghai Sixth People`s Hospital.Semi-quantitative assessment by Genant et al.was adapted in grading the fracture and grade1 deformity or higher was considered fractured.Results: The prevalence of vertebral fracture was 17.15% in all and was 16.99% for male only;17.27% for female only.Men are bear a higher prevalence in the age group below 70 yrs old(P<0.001)and women are more risky than man at any age group except for under 74 yrs old(P<0.001).Men are tended to undergo mild deformity,single onset and thoracic vertebral fracture while women are more risky to moderate or severe,double onset and lumbar vertebral fracture.Male single vertebral fracture detection rate,2 vertebral fracture detection rate and 3 above vertebrae fractures detection rates were: 60.7%,28.6% and 10.6%,and Female single vertebral body fracture detection rates,2 vertebral fracture detection rate and 3 or more vertebral fracture detection rate is 67.8%,20.7% and 11.5%,respectively.From the outskirts of the crowd,detection of vertebral compression fractures in men and women were higher than the center of the community(male vertebral fracture detection rate of 21.9%compared with 12.9% women,vertebral fracture detection rate of 18.9%compared to 15.7%).T11,T12 and L1 is the most prevalent in thoracic and lumbar spine respectively.The prevalence in uptown area is significantly higher than downtown area.Conclusions: This is the first and pioneering study focused on vertebral fracture of China.The prevalence of vertebral fracture in Shanghai is17.15% in total.Women are more risky than man at any age group except for under 69 yrs old.T11,T12 and L1 are the most prevalent in thoracic and lumbar spine respectively.The vertebral fracture in women of community-dwelling elderly in Shanghai is more severe than men.The prevalence in uptown area are significantly higher than downtown area. |
PDF Full Text Request