| Objective: Antifungal Kidney Failure An Tang is a clinically effective formula formulated by Professor Nan Zheng,the supervisor of DN,based on the key theory of the pathogenesis of DN: "Poison damages the kidney ligaments,and the evil ambushes the membrane origin",and has achieved good clinical efficacy.In this study,we observed the clinical efficacy of the formula through real-world research and controlled experiments on patients with the symptoms of thirsty kidney failure and Qi-Yin deficiency with stasis and toxicity,and objectively evaluated the clinical efficacy and safety of the formula in the treatment of thirsty kidney failure and Qi-Yin deficiency with stasis and toxicity,as well as the effectiveness of the formula in improving symptoms and alleviating renal fibrosis.The advantages of Chinese medicine in the treatment of diabetes mellitus were evaluated to provide new ideas and new methods for the treatment of diabetes mellitus.Methods1 Based on the "real world" data analysis method,we observed the clinical efficacy of the treatment of diabetic kidney disease in stage V with the treatment of thirsty kidney failure An Tang.From January 2019 to December 2020,212 patients with Qi and Yin deficiency and stasis and toxicity evidence of thirsty kidney failure who attended Prof.Nanzheng’s workshop were selected.12 cases with GFR reduction >30% within 2-3 months after the application of ARB or ACEI drugs during treatment were excluded,and 75 cases with less than 5 years of treatment and failed return visits were excluded.125 cases were finally enrolled.Baseline items,return items and endpoint time were recorded,and efficacy analysis,regression analysis and survival curve plotting were performed.2 A total of 63 patients were selected from the outpatient clinic and endocrine treatment area of Professor Nan Zheng’s workshop at the Affiliated Hospital of Changchun University of Traditional Chinese Medicine,with 32 patients in the herbal treatment group and 30 patients in the control group.The control group was directly grouped by the control method,in which the treatment group was given oral administration of the Chinese herbal medicine for kidney failure with external enema and "one rule and eight methods" control,while the control group was given oral administration of Haikun Renxi capsule with rectal administration of Renkang suppository and lifestyle control,a course of treatment was given for 3 weeks,and 3 courses of treatment were continuously observed.3 The expression of serum TGF-β1,MMP-9 and TIMP-1 were measured before and after treatment in both groups,the expression of urinary TGF-β1 was measured before and after treatment,and the content of MDA and the activity of SOD and GSH-Px in the urine of patients were measured.Results1 eGFR,fasting blood glucose,2h postprandial blood glucose and HBA1 c were independent risk factors for endpoint events in patients with thirsty kidney failure.The combination of oral administration of An Tang for Thirsty Kidney Failure with topical enemas and the "One Rule,Eight Methods" control was a protective indicator that reduced the incidence of endpoint events in patients with Qi-Yin deficiency with stasis and toxicity in Thirsty Kidney Failure,and was positively correlated with the duration of drug administration.2 The total effective rate was 81.25% in the 32 cases of Qi-Yin deficiency with stasis and toxicity evidence of thirsty kidney failure treated with An Tang and 70.97% in the control group.There was no significant difference in the overall efficacy of the two groups,but the main symptoms and clinical biochemical indexes of Chinese medicine were better in the treatment group than in the control group,and the improvement of clinical symptoms and various physical and chemical examination results were significantly better than those of the control group,which was statistically significant.There was statistical significance.3 Quenching and Thirsty Kidney Failure An Tang can reduce the expression of serum and urine TGF-β1 and TIMP-1 and increase the expression of serum and urine MMP-9,thus slowing down the process of kidney fibrosis,and the effect is better than that of the control group.4 Qiu Thirsty Kidney Failure An Tang was able to reduce the patients’ urinary MDA content and increase their urinary SOD and GSH-Px activity to improve the degree of renal fibrosis by alleviating the process of oxidative stress,and the effect was better than that of the control group.Conclusion: eGFR,fasting glucose,2h postprandial glucose and HBA1 c are independent risk factors for endpoint events in patients with thirsty kidney failure.The combination of oral administration of Anti-thirsty Kidney Failure An Tang with topical enemas and the "One Rule,Eight Methods" control was a protective indicator that reduced the incidence of endpoint events in patients with Qi-Yin deficiency with stasis and toxicity in Anti-thirsty Kidney Failure,and was positively correlated with the duration of drug administration.The treatment can significantly improve the symptoms and signs of patients with Qi-Yin deficiency and Stasis-Toxin evidence of thirsty kidney failure,as well as improve the laboratory indexes of patients with Xiang Gua,and reduce the expression of serum and urine TGF-β1 and TIMP-1,increase the expression of serum and urine MMP-9,reduce the urine MDA level and increase the urine SOD and GSH-Px activity of patients.Improving the degree of renal fibrosis by alleviating the process of oxidative stressAccording to Professor Nan Zheng,the key to the pathogenesis of thirsty kidney disease is that "toxicity damages the kidney ligaments,and evil entraps the membrane origin".In this experiment,the treatment method of "detoxifying the kidney ligaments,benefiting the kidney to reach the original" is combined with the modern medical treatment of renal fibrosis,which is the main manifestation of DKDV stage,to treat thirsty kidney failure by inhibiting oxidative stress in the kidney and alleviating and improving the process of renal fibrosis. |
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