Clinical Observation On The Treatment Of Coronary Heart Disease With Qi Deficiency And Phlegm Stasis And Water Decoction

Objective:To estimate the curative effect of JiaWeiJiaoMuGuaLou Decoction in treating coronary heart disease with heart failure and explore the mechanism of JiaWeiJiaoMuGuaLou Decoction in treating coronary heart disease with heart failure.Methods:Patients with chronic heart failure due to coronary heart disease from The First Hospital of Hunan University of Chinese Medicine were randomly divided into JiaWeiJiaoMuGuaLou Decoction treatment group(30cases) and conventional western medicine control group(30cases) with atreatment course of4weeks for both groups. Record the changes of TrationalChinese medical (TCM)symptom scoring,left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDD), ammo-terminal pro-brain natriuretic peptide(NT-proBNP) and6minute walking test (6MWT) which as therapeutic effect index. Test blood, urine,stool routine, liver function, renal function, electrolyte, etc, as safety indicators.Results:1.The total effective rates in treatment group and control group were86.67%and73.33%respectively, there was a significant difference between the two groups.2.Compared with the integration of traditional Chinese medicine syndrome before treatment, it reduced prominently after treatment in each group. There was a remarkable difference between the two groups after treatment.3.The total effective rates for traditional Chinese medicine syndromes in treatment group and control group were86.67%and76.67%respectively, there was a significant difference between the two groups.4.Compared with the LVEF before treatment, it increased prominently after treatment in each group. There was a conspicuous difference between the two groups after treatment.5.Compared with the LVEDD before treatment, it reduced prominently after treatment in each group. There was no apparent difference between the two groups after treatment.6.Compared with the plasma NT-proBNP level before treatment, it reduced obviously after treatment in each group. There was a prominent difference between the two groups after treatment.7.Compared with the6MWT before treatment, it improved prominently after treatment in each group. There was no apparent difference between the two groups after treatment.8. There was no severe adverse reaction in the period of observation.Conclusions:1JiaWeiJiaoMuGuaLou Decoction can improve the patients’ heart function.2. JiaWeiJiaoMuGuaLou Decoction can improve the patients’ symptoms and signs.3.JiaWeiJiaoMuGuaLou Decoction can raise patients’ LVEF through which strengthen cardiac contractive function.4. JiaWeiJiaoMuGuaLou Decoction can reduce patients’ plasma NT-proBNP. volume and pressure load to improve symptoms and signs.5. JiaWeiJiaoMuGuaLou Decoction is safe in the treatment of heart failure.