| Objective: To explore the levels of serum lipids and the relationship of serum lipids to other cardiovascular risk factors in rural school-children. Methods: Height, weight, blood pressure (BP) were measured among 933 children aged 7-14 years old in rural area of China. fasting serum glucose(FSG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) were determined with the 12-14h fasting blood sample. Body mass index (BMI), Low-density lipoprotein cholesterol (LDL-C) and TC/HDL-C ratios were calculated. The lifestyle, dietary habits, frequency of exercises in children and the family history of cardiovascular diseases were obtained by a questionnaire with 104 items. All statistical analyses were performed using SPSS, version 10.0. Means, standard deviation and percentiles were used to describe the characteristics of various serum lipid levels . Prevalence of the abnormal serum lipids was calculated according to the criteria suggested by the American National cholesterol Education Program (NCEP) in 1992. The levels of obesity, blood pressure, and fasting serum glucose were compared betweenthe children with normal serum lipids and the children with abnormal serum lipids. The odds ratio (OR) was used to estimate the risk of multiple risk factors for the abnormal serum lipids.Pearson correlation coefficients and partial correlation coefficients (adjusted for the effects of age and weight) were used to assess the relationship of serum lipids to the other indexes. The factors influencing serum lipids were determined by multiple stepwise regression analysis.Results: The 95% reference ranges for TC, TG, HDL-C and LDL-C were 2.24mmol/L~5.29mmol/L, 0.52mmol/L~ 3.01mmol/L, 0.66mmol/L~2.03mmol/L and 0.41mmol/L~ 3.40mmol/L respectively. The higher risk levels for TC,TG,HDL-C and LDL-C were 4.17 mmol/L,1.29 mmol/L ,1.13 mmol/L and 2.28 mmol/L respectively. TG levels increased along with the increasing of age but HDL-C levels decreased. TC and LDL-C levels had no singnificant difference in different age-groups. There was significant difference of serum lipids between boys and girls in some age groups. The levels of blood pressure, fasting serum glucose and obesity all were higher significantly in the group of abnormal serum lipids compared with the group of normal serum lipids. As the number of multiply factors increased, so did the OR of the higher TC, TG, LDL-C and the lower HDL-C. TC had positive correlation with FSG, TG(Ln), HDL-C, LDL-C, TC/HDL-C(P<0.01), but negative correlation withage, height, weight(P<0.05). TG had positive correlation with age, height, weight, BMI(Ln), TC, TC/HDL-C(P<0.01), but negative correlation with HDL-C, LDL-C(p<0.01). LDL-C had positive correlation with FSG, TC, TC/HDL-C(P<0.01), but negative correlation with age, height, TG(Ln), HDL-C(P<0.05). HDL-C had negative correlation correlated with age, height, weight, BMI(Ln), SBP, DBP, FSG, TG(Ln), LDL-C, TC/HDL-C(P<0.01), but positive correlation with TG(P<0.01). The results of multiple stepwise regression suggested that the factor influencing serum lipids in school-children were FSG, TG, HDL-C, LDL-C and TC/HDL-C for TC; BMI, TC, HDL-C, LDL-C and TC/HDL-C for TG; FSG, TC, TG and LDL-C for LDL-C; height, SBP, FSG, TC, TG, LDL-C and TC/HDL-C for HDL-C. In addition, there were no significant differences in the levels of serum lipids and other risk factors between the children with and without the family history of abnormal serum lipids.Conclusions: TG levels increased along with the increasing of age but HDL-C levels decreased. TC and LDL-C levels had no singnificant difference in different age-groups. There were significant differences of serum lipids between boys and girls at some age groups. Blood pressure, fasting serum glucose and obesity in children with abnormal serum lipids were higher significantly than those of children with normal serum lipids. As the number of multiply factorsincreased, so did the OR of the higher TC, TG, LDL-C and the lower HDL-C. Th...
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