Effects Of Qiweibaizhu Powder On IFN-γ And TNF-α And Intestinal Mucosal Thy-dependent Lymphocytes Of Sulkling Mice Infected With Human Rotavirus(HRV)

Objective: To study the effects of Qiweibaizhu Powder on IFN- y and TNF-a and intestinal mucosal thy-dependent lymphocytes of sulkling mice infected withHRV.Methods: The model of NIH sulkling mice infected with HRV orally were established and were randomly divided into 3 groups by home.The normal control group was treated with NS, and the other groups were treated with NS, Qiweibaizhu Powder,Ribavirin respectively for 7 days. IFN-gamma and TNF-alpha inblood serum and the number of CD3+,CD4+ and CD8+ cells of intestinal mucosal thy-dependent lymphocytes of sulkling mice infected with HRV were observed by the techniques of ELISA and SABC respectively.Results: IFN-gamma in blood serum in the group treated with Qiweibaizhu Powder was higher than that in the model group, difference between twogroups was significant ( p <0. 05 ) . TNF-alpha in blood serum in the group treated .with Qiweibaizhu Powder was lower than that in the model group, difference between two groups was significant ( p <0. 05 ) . The number of CD4+ cells of intestinal mucosal thy-dependent lymphocytes in thegroup treated with Qiweibaizhu Powder was higher than that in the model group, but the number of CD8+ cells of intestinal mucosal thy-dependent lymphocytes was lower than that in the model group, difference between two groups was significant ( p <0. 05).Conclusion: Qiweibaizhu Powder can enhance IFN-gamma in blood serum of sulkling mice infected with HRV, and reduce TNF- alpha in blood serum. Qiweibaizhu Powder can improve the number of CD4+ cells of intestinal mucosal thy-dependent lymphocytes of sulkling mice infected with HRV, and decrease the number of CD8+ cells.