| Hyperlipidemia is a cardinal risk factor that induce atherosclerosis(AS) and cardia-cerebrovascular disease. Because AS is the pathology basis of coronary heart disease,and that hyperlipidemia is the major risk factor of causing AS, so it has important meaning to protect and cure hyperlipidemia which will prevent the coronary artery atherosclerosis. KDZOL is was isolated from the whole plant of Ixeris sonchifolia olia (Bge.) Hance. Its effective contains is flavonoids and adenoisine. Objective To study the effect of Diemailing injection with Ixeris Sonchifolia (Bge.)Hance as raw materaial on the treatment of brain-thrombusbrain-embolism cardia- cerebrovascular-disease myocardial- infarction cardiac-arrhythmia and so on is confirmed effectively. When Diemailing injection is applied in clinical treatment,we find it can obviously adjust bloodlipid and reduse bloodviscosity. So we develop it as adjusting blood-lipid health- medicine. All these demonstrate that KDZOL can protect acute myocardialischemia heart and the effects are superior on that of Diemailing. In this study we observed the influence of KDZOL on cholesterol, lipoprotein-cholesterol metabolism and anti-oxidation effect etc. of experiment hyperlipidemia rat to provide new idea for clinical cure of coronary heart disease angina and prevention of AS. The model of experiment hyperlipidemia was established by giving lipid-riched feeds to seventy-two Wistar rats.KDZOL with dosage 10g herbs/kg.d(low dosage group),20g herbs/kg.d(mid-dosage group),40g herbs/kg.d(high dosage group)was given to observe the adjusting effect of KDZOL on TC,TG,LDL-c,HDL-c concentration in rat's serum,LPO concentration , SOD activity of serum and liver and the TXA2 and PGI2 of plasma was estimated .non-hyperlipemia rats and hyperlipemia rats feeding with Lovastatin was used as control group to verify whether the KDZOL have effect of adjusting plasma lipoprotein and anti-AS.When in hyperlipemia, the concentration of TC,TG and LDL-c decrease ,at the same time HDL-c increase. As satisefied adjusting bloodlipid medicine,should decrease the concentration of TC,TG,LDL-c,Apo-B and increase HDL-c Apo-A. So we investgate these results ,we can confirm that KDZOL with high and mid- dosage can decrease the raised TC,LDL-c concentration and TC/HDL-c,LDL-c/HDL-c ratio , and the high-dosage group can increase HDL-c of hyperlipemia rats.Reinforcement of Lipid peroxidation in hyperlipemia make the concentration of LPO increased. Excessive LPO induce AS by rising the TXA2 production , decreasing the PGI2, aggregating platelet in harmed endothelium.,facilitating atheromatous plaque formation and oxidizing the LDL and cholesterol .SOD, one of main anti-oxidase,protects the cell from harming of peroxidation lipid by removing free radical and inhibiting production of LPO. So the decreasing of the LPO and the activity of SOD in plasma is generally accepted as an useful index in evaluating the effect of drug applied in protection and cure of AS and cardiovascular disease related with AS.The result demonstrate that KDZOL with high and mid-dosage can ameliorate the lipid metabolism ,decrease the concentration of lipid peroxidation,increase the activity of anti-oxidase and improve the ability of anti-oxidation. These maybe one of the possible mechanism of KDZOL in adjusting plasma lipidprotein and prohibiting AS. Hyperlipemia, which refrain fibrinolytic effect, influence the function of platelet ,increase consistence of blood and plasma and induce the alteration of hemorheology etc.,cause AS. We observed that the blood viscosity of hyperlipemia rats raised markedly. KDZOL with high and mid-dosage can decrease the parameter of hemorheology of hyperlipemia rats distinctly. It demonstrate that KDZOL can decrease the hyperviscosity of blood,reduce the occurrence possibility of AS. PGI2 can eliminate the oxygen-derived free radical and inhibit oxidation .it's also an useful vascular dilatation material. PGI2 and TXA2 are totally different in f...
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