The Effect Of Different-time Low-dose Aspirin Intake On The Balance Of PGI₂-TXA₂

Objective: The platelet activity and vessel injury are two most important factors in many reasons to result in thrombosis. Then, antiplatelet therapy has become one of the most regular therapies in modern cardiovascular disease. Physiologic characteristic of platelet includes adhesion,aggregation and release. In the natural blood circulation, platelet neither conglutinates each other nor adheres to natural vessel wall endothelial cell. When integrality of vessel wall endothelial cell is injured, platelet will adhere to it, aggregate and release many substances which can promote ability of platelet coagulation and result in thrombosis. It is obvious that platelet activity is key to thrombosis. Circadian rhythm changes of platelet activity in healthy subjects and in some disease conditions have also been reported, platelet count,mean volume and aggregation were higher in morning. Thrombosis also lies in the balance of thromboxane A2(TxA2) and prostacyclin (PGI2). TxA2 promoting and attached to thrombosis can constrict vessel forcefully and improve platelet aggregation obviously. In opposition to TxA2, PGI2 confronting to thrombosis can dilate vessel and inhibit platelet aggregation. TxA2 exists in platelet and PGI2 in vessel wall endothelial cell which would be release...