The Performance Of Target-controlld Infusion Of Remifentanil In Chinese Elderly Patients

BackgroundTarget-controlled infusion (TCI) is a new technique that based on the pharmacokinetic and pharmacodynamic of an IV drug, anaesthetist can set and adjust the target concentration (plasm compartment concentration or effect compartment concentration) and infusion rates are altered automatically according to a pharmacokinetic model. The advantages that TCI has over the current method of continuous infusion pumps are myriad, including ease of use, Maintaining a constant plasma or effect compartment concentration of an IV anesthetic requires continuous adjustment of the infusion rate according to the pharmacokinetic properties of the drug. it have progressed to the point that they are background commonplace in operating rooms in a number of countries. Remifentanil is a new congener of the fentanyl family of opioids that was approved for use as a supplement to general anesthesia by the US Food and Drug Administration in 1996. The unique feature of remifentanil is its short- acting pharmacokinetic profile. Its ester structure renders it susceptible to widespread ester hydrolysis, resulting in very rapid metabolism. Several pharmacokinetic sets for remifentanil have been described, and one implemented as a self-contained TCI system for remifentanil-a 'Remifusor'that has recently been licensed in Europe, However, the pharmacokinetic variables of remifentanil have been obtained mainly in studies that do not exactly resemble current clinical practice; therefore, remifentanil concentrations may not be accurately predicted. This is especially true when there are pharmacokinetic interactions between the anesthetic...