Contribution Of Eotaxin-1 In The Pathogenesis Of Nasal Polyp

Objective:To investigate the contribution of eotaxin-1 in the pathogenesis of nasal polyp.Methods: Sixty cases of nasal polyps and fifteen cases of normal inferior turbinate mucosa and were used. In the group of nasal polyps, there were 40 cases accompanied with chronic sinusitis and 20 cases with fungal ball sinusitis. Immunohistochemical staining for eotaxin-1 protein and HE staining for eosinophils were performed in nasal polyps and inferior turbinate mucosa. Reverse transcriptase-polymerase chain reaction (RT-PCR) tests for eotaxin-1 messager RNA were performed in 5 cases of nasal polyps accompanied with chronic sinusitis and 2 cases with fungal ball sinusitis, and 2 cases of inferior turbinate mucosa.Results:â‘ Eotaxin-1 immunoreactivity was mostly detected in epithelium and some vascular endothelial cells. Some eosinophils and phagocytes in the stroma also were identified as eotaxin-1 positive cells.â‘¡Eotaxin-1 was constitutively expressed in inferior turbinate mucosa and highly expressed in nasal polyps(P<0.05).The increased expression of eotaxin-1 protein was higher in nasal polyps accompanied with fungal ball sinusitis than that with chronic sinusitis (P<0.05).â‘¢The distribution of eotaxin-1 immunoreactivity in the nasal polyps was found to almost coincide with the presence of eosinophils. Tissues eosinophilia in nasal polyps was associated with the expression of eotaxin-1 protein(P<0.01).â‘£Eotaxin-1mRNA is differently expressed in inferior...