Observation And Comparison On The Distribution Of The Inflammation Cells Of Nasal Polyp In Different Years

Objective:To explore the histologic changes and possible influence factors of nasal polyps in different years by observing the distribution of the inflammtian cells of nasal polyps, especially the change of the number of eosinophils.Methods:A retrospective study of 120 patients with nasal polyps from 1999 to 2009 in Zibo Center Hospital. Every 20 cases were selected overyears with equal proportion in gender and the age ranging from 20 to 40. All the cases were classified as typeⅡstage 1-3 according to the nasal polyps standard made by CMA in 1997, eliminating relevant diseases such as allergic rhinitis, nasal sinus neoplasms, cystic fibrosis, primary ciliary dyskinesia, fungal sinusitis and significant anatomy deformity. Besides, one week before the operation, no antibiotics and corticosteroids should be use.The nasal polyps of each patient were stained with HE to count the number of eosinophils, lymphocytes and neutrophils under a light microscope and were divided into 2 groups according to the number of eosinophils:(1)eosinophil infiltration and (2)noneosinophil infiltration, counting the number of three kinds cells in two groups. The data was analyzed with One-Way ANOVA.Results:Calculate the mean number of eosinophils, lymphocytes and neutrophils of 20 patients in each two years. There was no significant difference of the mean number between lymphocytes and neutrophils(P<0.05). The difference of the mean number of eosinophils among these years was significant (P＜0.05) and presented a uptrend year by year.The difference of the mean number among eosinophils, lymphocytes and neutrophils in two groups was significant. Eosinophils were found predominantly in the group of eosinophil infiltration, lymphocytes taking the second place, neutrophils the least. In the other group of noneosinophil infiltration, lymphocytes were found predominantly, eosinophils the second, neutrophils in this group was more than the other group. The recovery rate of nasal patients with nasal polyps in group of eosinophil infiltration was significantly inferior to the group of noneosinophil infiltration, also the curative time was sharply longer. The number of eosinophils was positive correlated with the curative time, but negative correlated with the number of lymphocytes. Conclusion:The number of eosinophils in nasal polyps presents a uptrend in the late 10 years with no significant changes on the lymphocytes and neutrophils. The more eosinophils infiltrate in the nasal polyps, the longer cure time it takes. In a word, the conclusion of our study may be helpful for the classification, mechanisms and the patient's prognosis evaluation of the nasal polyps.