Experimental Study On Action And Mechanism To Asthma Model By Zhichuang Decoction

Bronchial asthma is one of the important chronic diseases that seriously harmed the healthy of public in the world at present. Its etiological factor is various, pathogenesis is complicated. Airway nonspecific inflammation and air hyperreactivity (AHR) are the main character of this disease.The dissertation presents the research summarize progressed on the etiological fators, pathogenesis, and the most recent treatments of bronchial asthma from the TCM documents and the medicine documents. The infiltration of EOS and the imbalance of Th1/Th2 cytokines have the key action to the episode, pathogenesis and persistent of bronchial asthma.Zhi Chuang decoction, an effective prescription to bronchial asthma in clinic, could keep the inspired air going downward and dispel phlegm, and warm the kidney to help inspiration to relieve asthma. By establishing asthma model and selecting some indexes closely related to airway allergic inflammation, studying and discussing deeply the action and mechanism of Zhi Chuang decoction.In the experimental studies, on the level of entirety, cytokine, inflammatory factor, histomor and gene, by means of pharmacology, pathlolgy, immunoradiometry and immunohistochemistry, studying the action and mechanism of Zhi Chuang decoction to asthma model and the significance of compatibility of the two methods.Results: Zhi Chuang decoction can improve obviously the respiratory function of the asthma model and control obviously the airway inflammation. The mechanisms relate to restraint EOS'chemotaxis, promoting EOS'apoptosis and Th1/Th2 cytokines'regulation, and TNF and ICAM-1's regulation. It could reduce AHR. The mechanisms relate to control the airway inflammation. Conclusion: Zhi Chuang decoction has the actions of anti-inflammatory, immunoregulation.