Effect On AngⅡ And Heart Function Of Serum Of Experiment Rat With Congestive Heart Failure Treated By LiXinⅠ

Objective: To study the effect of Lixin I on the AngII and Heart function gravity of Serun of the experimental rat with Congestive Heart Failure.Methods: Adriamycin is applied to build CHF model, Eighty-four male wistar rats were randomly divided into six groups: normal control group, model group, CARVEDILOL TABLETS control group, XinBao control group, Low-dose LiXin I group, high-dose LiXin I group. The general condition and death rate of the rats are evaluated. Meanwhile, the rat's tissue morphology and myocardial ultrastructure change are measured. Moreover, AngII in the rats plasma are measured through radioimmunoassay.Results: Firstly, AngII of Serum of rat in the control model group is higher than in the normal control group (P<0.01). AngII of Serum of rat in the treatment groups is lower than in the control model group (P<0.01). AngII in the high dose LiXin I treatment model group is lower than in the medicine control group low dose LiXin I treatment grouprespectively. Difference between then is obvious (P<0.05) Secondly, LiXin I can improve the rats's homodymie, parameters, and heart function.Conclusions:1.The results show that Lixin I may play an important role of protecting and improving cardiac function through improving the CHF rat's dp/dtmax,dp/dtmin,LVSP, decrease LVEDP.2.LiXin I can decrease AngII of experimental rat with congestive heart failure. The best peutic efficiency is in the large dose.3. Lixin I is an effective prescription, depending on the basic law which is tonifying pneuma, warming Yang, promoting blood flow and using diuretic of gydragogue to alleviate water retention.