| Background: Ache vulgaris is a chronic and inflammatory skin disease involving in hair follicle and sebaceous gland that commonly occurs in adolescence and in young adulthood. It.is.commonly seen at department of dermatology, the major pathogenic factors involved are hyperkeratinization, obstruction of sebaceous follicles resulting from abnormal keratinization of the infundibular epithelium, stimulation of sebaceous gland secretion by androgens, and microbial colonization of pilosebaceous units by Propionibacterium aches, which promotes perifollicular inflammation. The lesions are often seen on the face, back and chest because the sebaceous glands in these regions are particularly active. It is characteristic of papules, pustule, node, cyst, and so on, with occurring repeatedly. Ache often appears on the surface of the facial skin, which has an effect on the beauty. With the improvement of the living conditions, people attach more and more importance to the treatment of the ache.Being founded from many researches, a majority of adult ache patients are female, and is durative. In western medicine, the main drugs for treating ache include the drugs of anti-androgen, the drugs that can restrict the secretionof sebaceous gland and anti-keratinization, antibiotics, vitamin and so on. In spite of numerous treatments available, they have some side-effect, no achetherapeutics has been found that is security, valid and ideal for women up to now.In traditional Chinese medicine, acne vulgaris is generally called as "lung-wind acne", it was recorded very early in Chinese literature. After systematically arranging historical records related to the pathogeny and mechanism of ache vulgaris, and carrying out an overview on literature in recent years, great advancement has been made in the understanding the pathogeny and mechanism of ache vulgaris in Traditional Chinese Medicine(TCM). The doctor of TCM form some new point of view that "Blood Deficiency", "Dampness and Heat", "Phlegm Accumulation", "Yin Deficiency of Kidney", "Liver Depression" and so on. For women, acne often outbreaks associated with menstruation, which is related to "Failure of the Liver to Dredge and Regulate" and "Dysfunction of Thoroughfare Vessel and Conception Vessel". The occurrence of ache vulgaris is closely associated with "Heat in Liver Meridian" besides "in Deficiency of Kidney" and "Yin Deficiency and Blood Heat". Based on the theory of above, we use Ziyin Qinggan Xiaocuo prescription (ZQXP, mainly composed of Fructus Ligustri Lucidi, Herba Ecliptae, Radix Bupleuri, Radix Curcumae, Radix Salviae Miltiorrhizae, Herba Houttuyniae, etc.) to treat ache of women. The therapeutic effect is satisfaction.Purpose: 1. In order to find a preparation of TCM, which has definite clinical effect and be convenience for taking, we use Single TCM concentrated Granules, of which Ziyin Qinggan Xiaocuo prescription Granules is composed. We study the clinical therapeutic effect of Ziyin Qinggan Xiaocuo prescription in treating female ache. 2. To research the applicability of Dermatology of Life Scales (DQOLS) and the Cardiff Ache Disability Index (CADI) in China, to convenient for the follow research about ache patients' life quality.Method: 1. One hundred and twenty about female ache vulgaris patients were randomized into two groups by random number table. The two groups received external application of Cuo Ling Tincture (CLT, mainly composed of Radix Salviae Miltiorrhizae, Radix Angelicae Dahuricae, Radix Astragali, etc.), and group A was treated with Ziyin Qinggan Xiaocuo prescription and group B with minocyclin additionally. The treatment lasted 28 days. 2. 120 female adult ache patients fill the forms before and after four weeks. Than analyze the reliability, validity and responsivity.Results: 1. In group A, 4 were cured, 14 markedly effective, 26 effective and 8 ineffective, the total effective rate being 84.6%. In group B, 5 were cured, 13 markedly effective, 25 effective and 5 ineffective, the total effective rate being 89.6%, which is similar to that in group A (P＞0.05). Adverse action was found in 7 patients of group A and in 9 of group B. 2. The quality of two life forms have well reliability and validity. But the responsivities have no statistical meaning. Conclusion: 1. Ziyin Qinggan Xiaocuo prescription has a good therapeutic effect for adult female acne vulgaris, which is similar to minocyclin. Meanwhile, ZQXP has less and slight adverse actions. 2. Both DQOLS and CADI have well reliability and validity, and they can be used to measure the quality of life for Chinese acne patients after amended. But the responsivity needs more studies. |
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