Inside And Outside Literature Analysis Of Traditional Chinese Medicine Treatment Of Acne Vulgaris And Chinese Medicine Clinical Study The Treatment Of Acne

This dissertation contains two relevant parts:the literature analysis of traditional Chinese medicine in the treatment of acne vulgaris, and the Clinical study of TCM internal and external treatment of acne vulgaris.1Literature analysis of traditional Chinese medicine in the treatment of acne vulgarisObjective:Though there are many modern literature of TCM in the treatment of acne vulgaris, there is no systematic summery on clinical medicine and syndrome differentiation type diversity. Based on the clinical literature of TCM in recent15years, this study analyzed and summarized the TCM treatment of acne vulgaris rules, and will provide a theoretical basis for clinical treatment and scientific research.Methods:Relevant literatures published from January1998to August2013on TCM treatment of acne were gathered and analyzed from CNKI. By reading the title and abstract, we removed reports that repeated or did not meet the inclusion criteria. And we use Excel2007to statistics and analysis, counting the frequency of TCM medicine use and acne type diversity.Result:1. A total of72articles met the criteria were selected, including128prescriptions,195kinds of medicinal herbs,43kinds of acne TCM syndrome.2. All TCM herbs appears2062times, the largest medicine frequency is79times, the minimum is1, the median is31times. The top ten are:Radix Scutellariae, licorice root, gardenia, Cortex Moutan, forsythia, radix paeoniae rubra, rehmannia, Salvia miltiorrhiza, dandelion, honeysuckle.192of195kinds of TCM herbs were recorded by "Pharmacy", covering18categories,28small classes. The top five are:heat clearing drug, the tonic medicine, promoting blood circulation and removing blood stasis drugs, diaphoretic, resolving phlegm and relieving cough and asthma medicine.3.In192kinds of traditional Chinese medicine, the most of four properties is cold, the most of five tastes is bitter, and the main meridian of traditional Chinese Medicine is liver channel tropism.4. In43kinds of TCM syndrome, the top five are:the lung by wind heat syndrome, gastrointestinal damp heat syndrome, the syndrome of disharmony, lung and stomach damp heat syndrome, and damp heat retention.43syndromes were summarized in the19types of syndromes, The top3are:damp heat type, lung heat type and phlegm and blood stasis type.5. To treat damp heat type acne, the top five use of TCM herb is:Yin Chen, Scutellaria, gardenia, rhubarb, and Oldenlandia diffusa, the top3of medicine category is heat clearing drugs, diuresis medicine, and diaphoretic; To treat lung heat type acne, the top five use of TCM herb is:the baikal skullcap root, mulberry bark, loquat leaf, raw land, and Radix glycyrrhizae, the top3of medicine category is heat clearing drug, diaphoretic drug, and promoting blood circulation and removing blood stasis drugs; To treat phlegm and blood stasis type acne, the top five use of TCM herb is:Prunella vulgaris, tangerine peel, licorice root, safflower, and Danshen, the top3of medicine category is heat clearing drug, promoting blood circulation and removing blood stasis drugs, and tonifying drug.Conclusion:The largest use of TCM herbs in clinical treatment of acne is heat clearing drugs. Clearing heat is the general principles through the acne treatment process. The most common types of acne are damp heat type, lung heat type and phlegm and blood stasis type.2Clinical study of TCM internal and external treatment of acne vulgaris.Objective:To observe the clinical curative effect of TCM treatment with Oral medicine and external mask, standardize herbal mask treatment process, and to evaluate the safety of this study.Methods:1. The acne patients who met the inclusion criteria were randomly assigned to the experimental group and the control group with3:1. The control group were divided into the lung by wind heat syndrome group, lung and stomach damp heat syndrome group and the phlegm and blood stasis syndrome group, according to TCM syndrome differentiation.2. The lung by wind heat syndrome group oral prescription No.1, and take external mask No.1treatment; The lung and stomach damp heat syndrome group oral prescription No.2, and take external mask No.2treatment; The phlegm and blood stasis syndrome group oral prescription No.3, and take external mask No.3treatment; The control group oral Danshentong Capsules and use0.3%Viaminate and Vitamin E Cream. All patients were treated for6weeks.3. All patients completed the observation table Before treatment and after2,4,6weeks treatment. The observation table record number of acne lesions, grades, scores of TCM symptoms and adverse reaction. After6weeks of treatment, the curative effect index was calculated.4. Numbers of both non inflammatory lesions and inflammatory lesions were recorded before treatment and after2,4,6weeks treatment. The two together is the total lesion score, which is used to calculate therapeutic index. At the same time, according to the grade of acne and TCM symptom score, we evaluated the clinical efficacy.5. By observing patients’blood test, urine test, liver and kidney function test results before and after treatment, and the adverse events occurred in the process, we evaluate the safety of this experiment.6. We use SPSS for windows19.0to statistics. All statistical tests were two-sided test, P<0.05shows significant differences.Result:1. After6weeks of treatment, the test group total effective rate was87.64%; the control group total efficiency is71.43%, the difference was statistically significant (P=0.003). The lung by wind heat group total effectiveness is87.50%, lung and stomach damp heat group total effectiveness is88.33%, phlegm and blood stasis group, the total effective rate was87.03%, all of which were higher than the control group, and the difference was statistically significant.(P=0.025,0.020å'Œ0.040)2. The acne level in both test group and control group were reduced after6weeks treatment, and the difference was statistically significant(P<0.05). In the test group, after6weeks treatment acne patients in grade III, IV decreased obviously, the number of patients with acne in grade II was unchanged, the number of grade I was increased.3. The TCM symptom score in both test group and control group were reduced. However, after6weeks treatment, there was significant difference in the changes of TCM symptom score (P<0.05). TCM symptom including bad breath, abdominal distension, constipation, red or yellow urine, dysmenorrhea reduced in varying degrees.4. The tests were completed in241cases. Patients’blood test, urine test, liver function, and renal function showed no abnormality before or after treatment. There were no found of seriously related adverse reactions associated with drug in the treatment of the whole process.Conclusion:1. Treatment of traditional Chinese medicine combined with Chinese herb mask on acne vulgaris showed significant clinical effect. It can obviously reduce the number of skin lesions with different types.2. This treatment can lower the level of patients with acne vulgaris and reduce its severity.3. It can effectively improve the symptoms of TCM.4. This treatment has high safety, little side effect, and is worth promoting.