The Study On The Effect Of Arotinolol On Anti-hypertensive And Anti-inflammatory In Middle-aged And Young Essential Hypertension Patients

Objective: To-observation of young patients with moderate hypertension before and after oral metoprolol-and-oral-arotinolol,-to-discuss-the-antihypertensive-effect-and-the-effects-of-inflammatory-factor: High-sensitive-C-reactive-protein(hs-CRP), Solubleness CD40 Ligang (SCD40L), the-influence-of-blood-lipids,-blood-sugar,-kidney-function.-To-compare-beta-blockers-metoprololand-arotinolol-the-antihypertensive-efficacy,-safety,-equability-and-anti-inflammatory-effects and-the-mechanism of action.Methods:Following discontinuation of any cardiovascular drugs for 2 weeks, 66 cases were blockedly randomized to two groups. 1. A group of metoprolol group: 30 patients with essential hypertension-were-treated-by-Metoprolol-12.5mg-twice-a-day-oral.-2.-B-group-of-Arotinolol-group:-36-patients-were-treated-by-Arotinolol-5mg-twice-a-day-oral.-After-2-weeks,-blood-pressure-still≥140/90mmHg,-Respectively-to-the-dose-doubling,-otherwise,-continue-to-the-original-dose.-Before-treatment-and-after-12-weeks-of-treatment,-calculated:-①anti-hypertensive-total-effective-rate,-24-hour-average-systolic-blood-pressure(24hMSBP),-24-hour-average-diastolic-blood-pressure(24hMDBP),-daytime-average-systolic-blood-pressure(DMSBP),-daytime-average-diastolic-blood-pressure(DMDBP),-nighttime-average-systolic-blood-pressure(NMSBP),-morning-average-systolic-blood-pressure(MSBP),-morning-average-diastolic-blood-pressure(MDBP),-24-hour-average-heart-rate(24hMHR),-daytime-average-heart-rate(DMHR),-nighttime-average-heart-rate(NMHR),-Blood-smoothness-index(SI)-and-Nocturnal-blood-pressure-decline-rate.-②-Plasma-was-assayed-for-hs-CRP,-SCD40Lusing-byiIImmunoturbidimetry-and-Enzymelinked-Immunosorbent Assay .Results:1.Antihypertensive-effect:⑴After twelve weeks the drug antihypertensive of A group has 76.7% efficiency, B group has88.8%. The total efficiency of the two groups have no significant difference(P=0.50).⑵After-12-weeks-treatment:①A-group-and-B-group-24hMSBP, 24hMDBP,-DMSBP, DMDBP,-NMSBP,-NMDBP-all-significantly-lower-than-before-treatment-all-have-statistical-significance (P<0.05). Compared the two groups, there was no significant difference (P>0.05).②A group of MSBP, MDBP, compared with those before treatment, there was no significant difference (P>0.05). B group of MSBP, MDBP, compared with those before treatment, the difference has statistical significance (P<0.01).③24hMHR, DMHR and NMHR decreased, the difference has statistical significance (P<0.01). Compared the two groups, there was no significant difference (P>0.05).④To compare with two group, in B group, SI has significantly increased. There were significant differences (P <0.01).⑤ambulatory blood pressure curve before and after treatment tips: A group of most of the separation of early at 6:00 and 7:00 have the cross, and B group blood pressure curve completely separate status.⑥A group of non- dippers after treatment only in patients with SBP restore dippers rhythm. The rhythm of DBP have little effect. B group of non-dipper patients with SBP, DBP restore dippers rhythm.2.-Comparison-of--blood-sugar,-blood-lipids,-renal-function:-The-two-groups-before-treatment-of-various-indicators-in-no-significant-difference(P>0.05).-①A-group-of-self-control-before-and-after-treatment: LDL-C,-Fasting-blood-glucose(P<0.05),-urine-β2-microglobulin-has-significantly-increased.-Insulin-sensitivity-index(ISI-)decreased-significantly(P<0.01).-②B-group-of-self-control-before-and-after-treatment:-TC,-24-hour-urinary-albumin(AIb),-β2-MG-decreased-significantly(P<0.01).-HDL-C,-ISI-increased-significantly(P<0.01).-③To-compare-with-two-group, in-B-group, TC, LDL-C, FBG, AIb,β2-MG-was-reduced-significantly(P<0.01). ISI, HDL-C-was-increased-significantly(P<0.01).-Both-have-statistically-significant-difference-to-compared .3.Serum-was-assayed-for-hs-CRP, SCD40L: The-two-groups-before-treatment-of-hs-CRP, SCD40L has no significant difference (P>0.05). After treatment, A group and B group hs-CRP, SCD40L level decreased significantly (P<0.05). Arotinolol group fell even more evident for this two indicators (P<0.01) . There were significant differences(P<0.01).Conclusions:Arotinolol-has-more-potent-antihypertensive-effect,-safety,-equability,-blood-pressure-variability-in-the-extent-of-small.-The-target-organ-has-a-better-protective-effect-and-more-effective-in-reducing the incidence of cardiovascular events. And can better slow down the inflammatory response to artery wall, Apply with coronary heart disease, Insulin resistance, diabetes, and renal failure middle-aged and young essential hypertension patients.