An Study Of Endothelial Function Of Brachial Artery,Ankle-brachial Index And Carotid Arteries In Patients With Diabetes Mellitus

Objective:To probe the correlaion between endothelium-dependent dilation of brachial artery(EDD),intima-media thickness of carotid(IMT) and ankle-brachial index (ABI)and the change of hemodynamic of carotid artery in patients with type-2 diabetes mellitus(T2DM).Methods: 31 cases of healthy volunteers as control groups,62 cases of diabets were devided into two groups by diabets course:diabets course <5 years as group A and diabets course >10 years as group B.In all subjects ,the EDD of brachial arteries,the IMT and hemodynamic of carotid arteries were measured with high resolution ultrasound,and the ABI was measured with sphygmomanometer.Results:The EDD in A group was significantly lower than that of the control group(P<0.01) ,and no significant difference were found in IMT,ABI and hemodynamic between A group and control group.Compared the B group with the A group and control group , EDD,ABI,PSV and EDVwere significantly decreased (P<0.01);S/D was increased(P<0.05); IMT,AT,PI and RI were significantly increased (P<0.01); EDD showed a significant negative correlation with IMT( r =-0.575,P <0.01),IMT showed a negative correlation with ABI(r=-0.521,P<0.01),EDD showed a significant positive correlation with ABI (r=0.492,P<0.01).Conclusions:The injure of EDD in T2DM was earlier than the change of IMT and ABI;The injure of EDD accelerated the proceed of antheroscl- erosis,caused the increase of IMT,the decrease of ABI and the change of hemodynamic.