Clinical Study On Predictive Value Of Ankle-brachial Index Combined With The Media Thickness Of Carotid Artery Intima In Coronary Heart Disease

Objective evaluation of predictive value of ankle-brachial index combined with the media thickness of Carotid artery intima in coronary heart disease.Methods 194 patients who had undergone the coronary angiography or percutaneous coronary intervention were recruited in our study from 2008 to 2010,male:144 patients;female:15 patients. The intima media thickness (TMT)of carotid artery and ankle-brachial index (ABI) were measured before operation. In addition, the hemostatic factors and history collection were also finished before operation. According to our study criterion, ABI≤0.9 was defined as positive, ABI> 0.9 was defined as negative, IMT≥0.9mm was defined as positive, IMT<0.9mm was defined as negative. The patients were divided into several groups:A group:the aboved two indicators were negative; B1 group:ABI was positive; B2 group:ABI was negative; C1 group:IMT was positive; C2 group:IMT was negative; D group:the aboved two indicators were all positive. The incidence of coronary heart disease (CHD) was confirmed according to the results of the coronary angiography.Results the incidence of CHD was 9.1% in A group,64.8% in B1 group,29.9% in B2 group,70.8% in C1 group,28.4% in C2 group and 89.1% in D group. The abnormal ABI had better predictive value in CHD (B1:64.8% versus B2:29.9%, P< 0.05). IMT also had statistical significance in the predictive value of CHD (C1:70.8% versus C2:28.4%, P<0.05), the positive predictive value of aboved two abnormal indicators in CHD was higher than that of one abnormal indicator (D:89.1% versus B1:64.8%, C1:70.8%, P<0.05), In addition, the negative predictive value of two combined negative indicators was also higher than that of one negative indicator (A: 9.1% versus B2:29.9%, C2:28.4%, P<0.01).Conclusions the combined two indicators of ABI and IMT have an important clinical significance in the predictive value of CHD.