Analysis Of Carotid Atherosclerosis' Related Risk Factors And The Study Of Relationship Between Progressive Cerebral Infarction And Carotid Atherosclerosis

Part 1 Relationship between carotid atherosclerosis and progressive cerebral infarctionObjective: To investigate the association between carotid atherosclerosis and progressive cerebral infarction.Methods: Carotid intima-media thickness(IMT) was measured by color Doppler ultrasonography in 331 patients with acute cerebral infarction, including progressive cerebral infarction and not. According to the results of ultrasonography, the patients were divided into three groups: normal(IMT≤0.9mm), arterial sclerosis(0.9mm1.5mm).Results: There are 80 patients who are progressive cerebral infarction(24.2﹪); There are 18 patients with progressive cerebral infarction in arterial sclerosis group, and 60 patients with progressive cerebral infarction in plaque group. Three point six percents of patients without arterial sclerosis or plaque were progressive cerebral infarction. The Logistic regression shows that the severity of carotid atherosclerosis is positively related to progressive cerebral infarction. Conclusion: There is a positive relationship between carotid atherosclerosis and progressive cerebral infarction. The severity of carotid atherosclerosis may be a risk predictor in progressive cerebral infarction.Part2 Relationship between related risk factors in patients with cerebral infarction and carotid atherosclerosis and the area of cerebral infarctionObjective: To investigate the association between the level of fibrinogen and carotid atherosclerosis(CAS) and the area of cerebral infarction, and the effects intensity of different risk factors on CAS.Methods: Carotid intima-media thickness(IMT) was measured by color Doppler ultrasonography in 508 patients with cerebral infarction, including lacunar infarction and cerebral infarction of larger area. According to the results of ultrasonography, the patients were divided into two groups: normal(IMT≤0.9mm), and carotid atherosclerosis (IMT > 0.9mm and plaque). The plasma fibrinogen and other biochemical markers were also detected. The history of hypertension, diabetes, smoking were also recorded.Resluts: According to the level of fibrinogen, all patients were divided into two groups:≤3 g/L group and >3 g/L group, logistic regression shows that the rate of >3 g/L group was 2.16. There were significant differences of age, fibrinogen, hypertension and smoking between the normal-carotid group and the carotid atherosclerosis group. Logistic regression shows that age, fibrinogen, hypertension and smoking significantly influenced on the CAS with the highest risk factor being the fibrinogen. Plasma fibrinogen was higher in lacunar infarction patients.Conclusions: In the patients with cerebral infarction, the elevated plasma fibrinogen was significantly correlated with CAS, and might play more important role than other traditional risk factors. The level of plasma fibrinogen is associated with lacunar infarction.