Clinical Study On Ziyin Qingre Method For Liver And Kidney-yin Deficiency Of Perimenopausal Syndrome

Objective:To Observe the treatment of Ziyin Qingre method for liver and kidney-yin deficiency of perimenopausal syndrome, evaluate clinical effect of Ziyin Qingre method for liver and kidney-yin deficiency of perimenopausal syndrome and explore its mechanism.Methods: 45 cases of patients of liver and kidney-yin deficiency of perimenopausal syndrome were randomly divided into treatment group and control group,the treatment group of 30 cases were treated with the Chinese medicine of Ziyin Qingre method, the control group of 15 cases were treated with Kuntai capsule. 4 weeks was a treatment course and observe two courses; the two groups were observed before and after administration of the main symptoms to improve the situation, level change of hemorheology and serum E₂, FSH, LH. To anlyse the effect of Chinesr medicine and its safety.Results: 1,Clinical effect: treatment group: cure rate was 10 percents, markedly effective rate was 50 percents, efficiency was 33.3 percents, inefficiency was 6.67 percents, the total effective rate was 93.33 percents. Control group: cure rate was 6.67 percents, markedly effective rate was 13.3 percents, efficiency was 46.7 percents, inefficiency was 33.3 percents, the total effective rate was 66.7 percents. Efficacy of the treatment group was superior to the control group. 2,Symptom score compared: the treatment group and the control group after treatment decreased their symptom score (P<0.01), and the contrast differences between the two groups before and after treatment there is obviously a significant (P<0.01), suggesting that the role of symptom improvement of the treatment group significantly better than the control group. 3,Comparative hemorheology: the treatment group and control group before and after treatment of whole blood viscosity at different shear rates (high shear whole blood (200/s), whole blood in the cut (30/s), whole blood low-shear (5/s), whole blood low shear (1/s)) under the decrease (P<0.01), but the contrast differences between the two groups before and after treatment there is obviously a significant (P<0.01). Suggesting that the role of decreasing whole blood viscosity and improving blood circulation of the treatment group significantly better than the control group. 4,Sex hormone comparison: the treatment group and control group before and after treatment of sex hormone E₂ both increase but no significant (P>0.01), sex hormone FSH, LH declined in varying degrees, the difference was not significant (P>0.01), suggesting that the treatment group and control group can be up to some extent at higher E₂ levels and lower FSH, LH level, but without statistical significance.5,The main symptoms of comparison: the two groups before and after treatment the main symptoms of sweat hot flashes, insomnia, irritability irritability, fatigue, etc. are both effective, to improve the situation and the effect of the treatment group was superior to the control group (P <0.01 & P <0.05).6,Security observation: no significant adverse reactions.Conclusion: The treatment of Ziyin Qingre method for liver and kidney-yin deficiency ofperimenopausal syndrome can significantly improve the patient's main symptoms; reduce bloodviscosity and improve microcirculation; increase to some extent at high E₂, lower FSH, LH levels,although not statistically significant. Therefore Ziyin Qingre method is to improve perimenopausalsymptoms syndrome, micro-circulation, endocrine and autonomic regulation, and enhanceimmune function in an effective way.