Analysis Of Essential Hypertension In Patients With Hyperuricemia Incidence And Risk Factors Of Health Examination In Qingdao

ObjectiveThe essential hypertension in patients with hyperuricemia incidence of Qingdao Municipal Hospital medical centers by prevalence survey to investigate the interaction between hypertension and hyperuricemia,analysis of risk factors. Through the health education, improving health ideas, change the Sub-health groups life behavior and diet, to actively early intervene for hyperuricemia.Thus, To prevent or delay the onset process of hypertension.MethodsThough random sampling survey for selected community patiens who were diagnosised with hypertension in health examination of Qingdao Municipal Hospital medical centers from Oct10,2007 to Oct10,2008,total 1940 cases. Useing questionnaire survey and medical test to make multivariate regression analysis, include general conditions(sex,age),lifestyle and behavior(Smoking, drinking,tea,fruits,vegetables intake,seafood and meat and eggs intake,cooking oil daily intake, the daily salt intake, daily sugar intake),investigation of family history, At the same time for medical examination, including height, weight, blood pressure (hypertension grade), common carotid artery diameter and biochemical indicators (cholesterol,triglycerides,blood glucose,high-density lipoprotein-cholesterol,low density lipoprotein-cholesterol,apolipoprotein A1, apolipoprotein B were determined.Using case-control study,application of SPSS18.0 and SAS8.0 software statistical description of the above information,t test,χ2test,non-conditional logistic regression (forward step by step method: likelihood ratio) and the Spearman rank correlation, analysis of data.Results(1)The study of sample population were 1940 hypertensive patients, of which 1653 were male;287 were female. Males significantly more than women.(2) Age distribution of the sample population is skewed (Skewness coefficient test of normality=0.468,Kurtosis coefficient=-0.387). The largest number of 36-40 age group there are 316 people,16 percent of the total. Aged over 80 are 16 people, is the smallest number,1 percent of the total. Average age of the Sample were 46.35±14.087,average age of male were 46.35±13.890 years old, female were 46.37±15.198,the average age of men and women was no significant difference (t=0.019,P=0.985).(3)Grades1 hypertension of the sample population were 1666, including male 1385,female 281;grades 2 hypertension were 169 person,all male;grades 3 hypertension were 105 person, including 99 males and 6 females. All levels of hypertensive patients, males were more than females (χ2=41.889,P<0.01).(4)Among the graded groups,the levels of APOA1,HDL was no significant difference between the groups.APOB: betweenⅠandⅢgroups were difference,P<0.05.Internal diameter of carotid artery and SUA:betweenⅡandⅢgroups were difference,P<0.05;betweenⅠandⅢgroups were difference,P<0.01.SUA increased along with the blood pressure,the spearman correlation coefficient was 0.516,P<0.01.TG:betweenⅠandⅡgroups were difference,P<0.05;betweenⅠandⅢgroups were difference,P <0.01.TC:betweenⅠandⅢgroups were difference,P<0.01.LDL:betweenⅠandⅢgroups were difference,P<0.05;betweenⅠandⅡgroups were difference,P <0.01.(5)The sample population is divided into two groups.Case group: hypertension and hyperuricemia were 584 cases,including 489 male and 95 female.Control group:only hypertension,but no hyperuricemia were 1356 cases,including 1164 male and 192 female.Case group and control group showed sex ratio was no significant difference(χ2=1.439,P=0.230).(6)The average age of case group patients were 48.94±12.568,and the control group were 45.24±14.556,case group were significantly older than the control group (t= 5.669,P<0.01).In the case group,the largest number of 46-50 age group there are 109 people,19 percent of the total;the smallest number of aged over 80 are 6 people,1 percent of the total.(7)In this study,patients with hypertension and hyperuricemia as 584 person,prevalence rate was 30.10%;of which 489 were male,prevalence rate was 29.58%;of which 95 were male,prevalence rate was 33.1%,prevalence of men and women were no significant differences (χ2=1.439, P=0.230).(8) The average age of male in case group were 49.28±12.040 years; the average age of female were 47.20±4.949 years.Prevalence of men and women was found no significant differences in case group(t=1.276,P=0.205). The average age of male in control group were 45.12±14.426 years;the average age of female were 45.95±15.342 years. Prevalence of men and women was found no significant differences in control group(t=1.276,P=0.461). The average age of female was found no significant between case group and control group(t=0.653,P=0.541).The average age of male in case group were significantly older than the control group (t=6.003,P<0.01). (9)In the case group, hypertension of grades 1,2 and 3 were 310,169 and 105 person,and all the control group were grade 1.The hypertension of grades 2,3were significantly higher than in control group(χ2=740.458,P<0.01). (10) In the control group, the average level of SUA were 330.31±56.217μmol/L,including female were 280.63±43.157μmol/L and male were 338.51±53.865μmol/L. In the case group, the average level of SUA were 479.89±56.219μmol/L,including female were 405.17±49.009μmol/L and male were 494.41±44.889μmol/L. In case group of the SUA level was significantly higher than control group (t=53.756,P<0.01). In the control group,SUA levels of the male were significantly higher than female(t=14.158,P<0.01).In the case group,SUA levels of the male were significantly higher than female(t=17.462,P<0.01).(11)In the case group,slightly higher BMI(BMI>24),smoking,drinking,and significantly higher than the control group. However, the normal daily intake ratio of tea, seafood, eggs, meat, cooking oil were significantly lower than the control group.(12) Patients with hypertension risk factors of hyperuricemia including male,old age,body mass index is too large, high blood pressure, drinking, family history of hypertension, daily excessive intake of seafood, meat and eggs,and daily intake of enough fruits and vegetables, drink tea were protective factors.(13) The SUA levels of hypertensive patients with hyperuricemia and among the various risk factors are relevant, P<0.01.Conclusion(1) In the study,all age groups with hypertension,the blood pressure levels, the number of men were significantly more than women.(2)In the study, the age with hypertension presented a normal distribution, the average age of non-discrimination between men and women, but essential hypertension and hyperuricemia group were significantly older than simple essential hypertension.(3)In the study,men and women with hypertension in the prevalence of hyperuricemia were no difference,the highest prevalence is the middle-aged (46-50 years), and the lowest prevalence is the young (<26 years). Male serum uric acid levels were significantly higher than the female. (4) In the study, the hypertension with elevated level of SUA levels were related to with age, clinical stage of hypertension, lipid metabolism, lifestyle and behavior, family history.The increase in SUA was also linked but not strongly to the carotid artery internal diameter.(5)The hypertension prevalence of hyperuricemia were related to the environment,diet and lifestyle. Lifestyle changes, such as reducing fat and carbohydrate food intake, avoid high-purine diet food and reasonable diet, early-risk populations for health education and guidance,may prevent or reduce the incidence of hyperuricemia,delay or reduce the long-term damage of hypertension.