Clinical Research Between Silent Brain Infarction With Coronary Heart Disease

Objective:To investigate the association between silent cerebral infarction(SBI) and coronary artery disease(CAD), and provide theoretical basis for prevention and treatment to achieve early prevention purposes.Methods : From January 2009 to April 2011, 330 consencutive hospitalized patients(234 males and 96 females, mean age 64.79±10.18 years) who were proved CAD by coronary angiography. All patients accepted MR examination of brain 1-week after angiography. Then all subjects were evaluated for coronary angiography score and Gensini score. Plasma concertrations of high sensitivity C-reactive protein and homocysteine were measured and analysed.Results:1. Compared with NCAD group, CAD group had a higher combined with SBI(64%); 2. In patients with coronary artery disease, (1) Compared with ABI group, SBI group had a significantly older age(67.14±9.77 vs 60.79±9.65 years, P<0.001); (2) There were 144 patients(69.2%) complicated stenosis of left anterior descending of coronary artery in SBI patients; (3) Logistic regression analysis showed that the presence of SBI was independently associated with age(OR 1.070,95%CI:1.032-1.108; P <0.001), history of hypertension(OR 2.195, 95%CI:1.104-4.366; P <0.05), Hcy(OR 1.035, 95% CI:0.962-1.113; P <0.05), CAS(OR 1.776, 95%CI:1.049-3.007; P <0.05), Gensini score(OR 1.039, 95%CI:1.013-1.066; P <0.005).Conclusion:There is a significant positive correlation between CAD and SBI. In patients with coronary artery disease, age, history of hypertension, Hcy, coronary angiography score and Gensini score were the risk factors of silent cerebral infarction. The evaluation of CAD may be useful to identify these patients at high risk for SBI.