The Research On The Affect Of Atorvastatin On Oxidative Stress And Lipid Peroxidation In Senile Ischemic Stroke

Objective To detect the change of plasmic 8 Isoprostan Prostaglandin F2alpha (8-iso-PGF2α) and Oxidized Low Density Lipoprotein(ox-LDL) in the elderly patients with acute cerebral infarction by atorvastatin. To Explain the affect by atorvastatin about Oxidative stress and Lipid peroxidation in Senile Ischemic stroke ,and provide Antioxidant treatment of acute cerebral infarction clinical basis by atorvastatin.Methods Randomly selected 57 cases acute cerebral infarction patients over the age of 60 years,admitted to Neurology of Anhui Provincial Hospital from October in 2009 to July in 2010(Confirmed by CT and MRI),30 cases were treated by atorvastatin, other 27cases were in control group .All blood samples anticoagulated were dealed with centrifugation.All the blood samples were analyzed by enzyme linked immunosorbent assay (ELISA )to detect 8-iso-PGF2αand ox-LDL at admission and after 10~14 days later . They were made comparison and statistical analysis.Results After treated 10~14 days later the test group 8-iso-PGF2αand ox-LDL were not change more .but the control group were changed obviously Their difference have statistically significant(P<0.05). After treated 10~14 days the level of the lipids between the test group and the control group have no statistically significant. After treated 10~14 days ,do neurological for all patients for efficacy evaluation,the result display that the test group's efficient is higher than the control group's.but have no statistically significant. Conclusions Atorvastatin have affects in Anti-Oxidative stress and Anti-Lipid peroxidation outside the Lipid Metabolism. Maybe can improve positive affect in eldly acute cerebral infarction for clinical Prognosis.