| Objective: To study the serum Oxidized Low Density Lipoprotein concentration of acute cerebral infarction after onset, and to evaluate their association with neural functional deficit degree in admission,activities of daily living(scale),the size of cerebral infarction,types and other lipid marker etc.Method: A case-control study was carried out at affiliated hospital of North China Coal Medical College, 90 ACI patients were selected in Neurological Department of the hospital from January 2007 to October 2007. 90 healthy examined subjects were selected as controls,the age , gender and anamnesis of two groups were matched. To acquire the informations:general condition,smoking,drinking, occurring,treatment of acute cerebral infarction, cerebral infarction complication of subjects etc; The biochemical parameters were measured by automatic biochemical analyzer; The oxidized low density lipoprotein were determined by ELISA in patients with cerebral infarctionat days l,14 after onset and in control subjects. The neurological status was evaluated by the standard of clinical neural functional deficit degree score in patients with Cl in adimission and the patients were divided into three groups: varmitus type,medium一sized type and gravis type. The size of infracted brain area was based on cranial CT data from 3 to 7 days in hospital and the patients were divided into three groups:. small cerebral infarction, medium cerebral infarction and large cerebral infarction. The patients were also divided into twe groups:. acute progressive cerebral infarction and nonprogressive cerebral infarction , palindromia lesions and the first lesions, multiple lesions and single lesion.Functional outcome was measured with the activities of daily living(ADL)Barthel index score at discharge from the hospital. Datas were put into the computer with the software of Excel and were analyzed by SPSS 13.0 statistics package,including t-test,χ2-test , the analysis of variance, Pearson product-moment correlation,partial correlation analyses and mutiple Logistic regression analyses..Probability value was considered significant when <0.05.Results:①There are no significicant difference between normal control groups and patients with acute cerebral infarction groups in age and gender.(P>0.05).At the risk factors for acute cerebral infarction smoking index,drinking,anamnesis , there are no significicant difference between the two groups(P>0.05).②. TG,APOB,LP(a),UA and FBS were significantly higher between patients with ACI and norma l controls(P<0.05),HDLC,AOPA were significantly lower than those of controls(P<0.05), TC,LDLC were no difference between than those of controls (P>0.05).③T he concentrations of serum Ox-LDL was higher in patients with ACI than in norma l controls(4.699ug/dl)(P﹤0.05),And there was significant difference between that(5.558ug/dl) on the first day and that(6.092ug/dl) on the fourteenth day (P<0.05)④The difference of concentrations of serum Ox-LDL is observed among the three groups differently on the first day, namely, the higher the serum concentrations of Ox-LDL is, the higher is the score of neurologic impairment and the larger is the volum of cerebral infarction.⑤The concentrations of serum Ox-LDL were no difference between patients with acute progressive cerebral infarction and nonprogressive cerebralinfarction, multiple lesions and single lesions on the same day(P>0.05),but it is significantly higher between patients with palindromia lesions and the first lesions(P<0.05).⑥The concentration of serum Ox-LDL was significantly negatively correlated with the activities of daily living(ADL)Barthel index score at discharge from the hospital. ( P﹤0.05 );⑦The concentration of serum LP(a) was significantly different among the different cerebral infarction groups(p<0.05),and were significant higher in patients with large cerebral infarction groups compared with medium cerebral infarction groups and small cerebral infarction groups(p<0.05). The concentration of serum LDLC,APOB and other lipid marker was not significantly correlated with cerebral infarction, neurological status and functional outcome ( P>0.05 ) .⑧The concentration of serum Ox-LDL was significantly positively correlated with the level of UC and LP(a) (P﹤0.05) and was not significantly correlated with other outine lipid marker in patient with ACI(P>0.05). The concentration of serum Ox-LDL was negatively correlated with TB in patient with ACI,but it was no significicant difference(P>0.05). The concentration of serum Ox-LDL was not significantly correlated with UC ,LP(a),TB and other outine lipid marker in normal control groups ( P > 0.05 ) .⑨APOB,DBP and, Ox-LDL are related independently and significantly with ACI by multiple Logistic regression analyses.Conclusions:①The concentrations of serum Ox-LDL was higher in patients with ACI than in normal controls ,And there was significant difference between that on the first day and that on the fourteenth day , palindromia lesions and the first lesions .②Serum concentrations of Ox-LDL in patients with ACl reflect Cl degree and extent,and may be correlated with functional outcome. |
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