| Objectives This study aims to investigate the relationship of oxidized low density lipoprotein(Ox LDL)and residual cholesterol(RC)with carotid artery plaque and cognitive impairment in patients with acute cerebral infarction.Methods 1 Patients with ACI who were hospitalized in the neurology department of Neurology,Hebei Provincial People’s Hospital from December 2019 to October 2021were selected as the case group(n=110),and those who underwent physical examination in the Hebei Provincial People’s Hospital during the same period were elected as the control group(n=72).The general data and the results of related laboratory tests of patients were collected.The RC was calculated according to the formula and the serum levels of Ox LDL was measured by enzyme-linked immunosorbent assay.Based on the stability of carotid plaques,the case group were divided into a stable plaque group and an unstable plaque group.The clinical data and serum Ox LDL and RC levels of the two groups were analyzed.2 A total of 48 patients who completed the Mini-mental state examination(MMSE)and the Montreal cognitive assessment(Mo CA)within 3-6months after the onset of ACI were selected as the research subjects.The included patients were divided into normal cognitive state and impaired cognitive state,according to the results of Mo CA scores,and their serum Ox LDL and RC levels was analyzed.Results 1 There were 106(96.40%)carotid plaques in the ACI group and 48(66.70%)in the control group.There were significant differences between the two groups in plaque crouse score,fasting blood glucose,total cholesterol,low-density lipoprotein cholesterol,monocyte count and monocyte-to-high-density lipoprotein ratio(P<0.05).2 There were significant differences in Ox LDL and RC levels between the ACI group and the control group,and the Ox LDL and RC levels in the moderate and severe ACI group were higher than those in the mild cerebral ACI group,and the difference was significant(P=0.006,P=0.009).3 Spearman correlation analysis showed that Ox LDL were positively correlated with total cholesterol(r=0.194,P=0.009),low-density lipoprotein cholesterol(r=0.202,P=0.006)and carotid plaque(r=0.302,P<0.001),plaque crouse score(r=0.175,P=0.018)and RC were positively correlated with total cholesterol(r=0.560,P<0.001),low-density lipoprotein cholesterol(r=0.443,P<0.001)and carotid plaque(r=0.157,P=0.034).4 The analysis results of serum Ox LDL and RC levels and carotid plaques in patients with ACI showed that the levels of Ox LDL and RC in the unstable plaque team were higher than those in the stable plaque team in ACI patients,and the difference was statistically significant(P<0.05).5 Multivariate Logistic regression results showed that Ox LDL(OR=3.311,95%CI: 1.192-9.196,P=0.022)and RC(OR=3.214,95%CI: 1.135-9.104,P=0.028)were risk factors for unstable carotid plaque in patients with ACI.6 In ACI patients,the level of Ox LDL was higher in the impaired cognitive state team than in the normal cognitive state team,and the difference was statistically significant(P=0.028).There is no difference in the level of RC between the two groups(P>0.05).Multivariate logistic regression analysis showed that Ox LDL(OR=1.007,95%CI: 1.001-1.013,P=0.032)was a risk factor for cognitive impairment in ACI patients after adjustment for other confounding factors.Conclusions 1 ACI patients had higher rates of carotid plaque formation.2 The level of serum Ox LDL and RC increased in ACI patients,and serum Ox LDL and RC in moderatesevere patients were higher than those in mild patients.3 The level of serum Ox LDL and RC are associated with carotid plaque stability in ACI patients,and are risk factors for the development of unstable carotid plaque in ACI patients.4 The level of serum Ox LDL was related to and was a risk factor for cognitive impairment in ACI patients.Figure 0;Table 16;Reference 145... |
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