The Clinical Significance Of Perioperative Detection Of Related Serum Tumor Markers In Patients With Non-small Cell Lung Cancer

Objective: To detect the levels of perioperative serum cytokeratin 19 fragment (CYFRA21-1 ),carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC) ,and to analyze the clinical value in patients with NSCLC.Methods: The levels of serum CYFRA21-1, CEA and SCC were detected before operation (d0), postoperative day 1(d1) and postoperative day 7 (d7) from 50 patients with non-small cell lung cancer (NSCLC) who underwent surgical resection, meamwhile the clinical relevance was analyzed.Results: The perioperative levels of CYFRA21-1 and CEA in patients with NSCLC were not different (P>0.05).The perioperative level of SCC rose first, and then declined, there were statistical significances (P<0.05).The preoperative levels of CYFRA21-1 as well as SCC in squamous carcinoma were significantly higher than that in adenocarcinoma (P<0.05). The preoperative level of CEA in adenocarcinoma were significantly higher than that in squamous carcinoma (P<0.05). The perioperative levels of CYFRA21-1 and CEA in advanced stage (III/IV) NSCLC were significantly higher than that in early stage (I/II) ones (P<0.05). The postoperative levels of CYFRA21-1 and SCC were significantly lower than preoperative ones in patients underwent radical resection (P<0.05).The perioperative levels of CYFRA21-1 as well as SCC in radical resection group were significantly lower than that in palliative resection group (P<0.05).Conclusion: To monitor the levels of perioperative serum tumor markers is helpful for knowing the invisible tumor burden of NSCLC patients. There are relationships between the perioperative levels of serum tumor markers and extention of resection, stage and pathological type. Both CYFRA21-1 and SCC are more suitable for monitoring squamous carcinoma, meanwhile CEA is more suitable for adenocarcinoma.