| Objective: To study the variation of different period serum ferritin (SF) for acute ischemic stroke and correlation and clinical significance between serum ferritin (SF) and progressive ischemic stroke ( PIS).Methods: A total of 133 acute ischemic stroke patients within 24 hours as the case group were selected recruited from October 2009 to November 2010 in the department of neurology at the affiliated hospital of Hebei Unite University, All patients were diagnosed as cerebral accidents by CT or MRI according to the criteria established in China Medical Association Cerebral Diseases meeting in 1995. The patients were divided into Case group:PIS group(50 patients); Control group: NPIS group(83 patients). The neurological status was evaluated by the standard of clinical neural functional deficit degree score(CSS) in patients with ischemic stroke at days l, 7 after stroke onset and the patients were divided into three groups: varmitus type, medium-sized type and gravis type. The size of infracted brain volum was based on cranial CT or MRI data in hospital and the patients were divided into three groups: small cerebral infarction, medium cerebral infarction and large cerebral infarction. According to carotid artery ultrasound examination were divided into non-plaque group, hard plaque group, soft plaque group, blend plaque grou. The Graduate student conducted face to face interviews and filled investigation forms which included information on the results of CT, MRI and DWI, the ultrasound of carotid artery with patients with acute ischemic stroke. Two blood sample (5ml vein blood) was collected in the case group on days 1, 3, 7 after admission. The blood sample were divided into two statistically significant tubes: one of them (3 ml) was sent to the lab for tests of fast blood sugar, blood lipid, white blood cell, fibrinogen and other serum lipids, the other sample (2 ml) was kept for 1-2 hours. After being centrifuged, the 2ml serum was stored in refrigerator (-80℃).Thelevelsof serum ferritin (SF) by Radioimmunoassay method and solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) determination of ox-LDL within one month.Datas were put into the computer with the software of Excel and were analyzed by SPSS 13.0 statistics package. Measurement data were indicated by mean±standard deviation, with t-test between two groups, one -way analysis of variance among groups and reapeated measures analysis of variance in the different time spot. numeration data were analyzed by x2 -test. Multiple logistic regression was used for identifying the relationship between progressive ischemic stroke and other risk factors.Results:1. The levels of ox-LDL,LDL-C, Fib, FPG, Soft plaque in patients with PIS were significantly higher than that of not PIS.(P<0.05).2. The SF level of PIS group at 1, 3, and 7 day were higher than that of not PIS group (P<0.001).3. With the higher level of SF, the progressiv risk was higher, (x2=20.63, P<0.001).4. ROC curves analysis showed that with elevated levels of SF in the first days after hospitalized, feasibility the more of patients regard for progressive ischemic stroke. When SF>280μg/L, as a kingdom of prediction value for ischemic stroke progress.5. Multiple logistic regression(Enter)showed SF and ox-LDL, Soft plaque were introduced into the modal.6. The larger the volum of cerebral infarction, the higher the score of neurologic impairment is,the higher the serum concentrations of SF is.Conclusions:1. Elevated SF levels is the important risk factors for progressive ischemic stroke.2. As early SF levels of ischemic stroke patients rose, the risk of disease progression increased. 3.The level of SF may reflect neurologic impairment degree and the size of infracted brain volum in progressive ischemic stroke. |
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