| Objective:In this paper, treatment group as control, evaluation of Integrative Medicine Kidney Yin Deficiency type DUB luteal insufficiency the clinical efficacy and clinical safety, and to explore its possible mechanism of action, clinical application of its scientific basis.Method:1. All the information from May 2009 to November 2010 in Hubei Province Chinese Medicine Hospital gynecology clinic patients were diagnosed with kidney Qi and Yin Deficiency type DUB luteal insufficiency, a total of 60 cases. In accordance with the principle of randomization,60 patients were divided into treatment and control groups, groups of 30 cases. Statistical analysis, the two groups in age, duration of disease, illness, etc. There was no significant difference (P> 0.05), comparable.2. The control group at the beginning of the menstrual cycle, the first 5d given clomiphene citrate orally,1 time per night, per 100mg (2 tablets), even the service is only 5d. Treatment group in the control group on the basis of oral clomiphene citrate, menstrual cycle from the beginning of the first 16d Oral decoction plus complement, the main drugs are:habitat, Moreover, Eclipta, Cistanche, Cuscuta, Sichuan off, psoralen, wolfberry, Ligustrum lucidum, Chinese yam, Chong Wei son, white peony root, and even served 15d, the Yin and kidney treatment, heat menstruation. Menstrual cycle as a course of continuous treatment in both groups for 3 courses, after the observation, assessment, treatment group by observing the results of evaluation of the efficacy and safety.3. The two groups in the course of treatment for safety were observed (blood, urine, stool; electrocardiogram, liver function, kidney function before and after treatment time) and the efficacy of detection (observation items:TCM, mid-luteal plasma progesterone (P) concentrations were measured, HPS score; B-ultrasound:uterine, accessories, follicular growth, endometrial thickness, ovulation.4. Were integrated effect of the two groups before and after treatment, Western medicine and TCM syndrome score, and laboratory examination Results midluteal plasma progesterone (P) concentrations were measured, HPS score results of the two treatment methods were effective in clinical observation.5. Statistical Methods:Using SPSS17.0 for statistical data analysis and processing software package. Column Ridit level analysis of count data line x2 test, t test measurement data line, and the normal distribution does not match the two samples were then used rank sum test; P<0.05 was considered statistically significant.Results:1. Comparison of clinical efficacy1.1 The total effect of the two groups were compared, treatment group, the total effective rate was 96.67%; control group, the total effective rate was 80.00%. The Ridit analysis, the total effect of the two groups were significantly different (P<0.05).1.2 The effect of the two groups were compared TCM, TCM treatment group were significantly improved (P<0.05), the control group to advance through, the color, quality anomalies, five upset hot, dry stool, dizziness, tinnitus, less Gas lazy words, lack of energy in these syndromes significantly improved (P<0.05), for dry mouth, lumbosacral pain, hot flashes, short red urine no obvious improvement in these syndromes (P> 0.05). TCM treatment group than the control group improved (P<0.05).1.3 The two groups were compared before and after treatment HPS scores, suggesting that both groups could improve the situation BBT, and the effect of the treatment group better than the control group (P<0.05).1.4 The two groups of patients before and after treatment mid-luteal serum P values compared, indicating that both groups could improve the mid-luteal serum P values, and the effect of the treatment group better than the control group (P<0.05).2. Correlation AnalysisThe efficacy of the treatment group and age of patients was significantly correlated (P<0.05), and duration, no significant correlation between the disease (P>0.05). That younger patients, efficacy is better; older, the worse the prognosis.3. Safety AnalysisTreatment group before and after treatment in patients with blood,urine,stool, ECG, liver function, kidney function abnormalities were not obvious, nor the course of treatment discomfort and allergic reactions to any complains, suggesting that the treatment had no significant side effects and adverse reactions.Conclusion:In this study, LPD dysfunctional uterine bleeding understanding of the characteristics of the pathogenesis of kidney Qi and Yin Deficiency is based, then in accordance with the principles of randomized controlled observation of 60 cases of LPD of dysfunctional uterine bleeding in patients with kidney Qi and Yin Deficiency type Clinical efficacy. Western ovulation control group, treatment group with Western medicine yin kidney ovulation+heat menstruation. Comprehensive efficacy, efficacy and Western medicine syndromes in terms of both the treatment group than the control group, confirmed the Integrative Medicine LPD of the effectiveness of dysfunctional uterine bleeding. Ovulation by Western medicine yin kidney+heat treatment of the analysis of menstruation, discussed its LPD dysfunctional uterine bleeding and its mechanism.Integrative Medicine LPD dysfunctional uterine bleeding medication convenience, compliance, and no significant side effects, it is worth further study and clinical application. |
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