Risk Factor Disscussion Of Diabetic Peripheral Neuropathy With Type2Diabetes

Objective: Through BioThesiometer mensurable sensation examination，10gramme nylon silk examine，Tip Therm temperature sensation examination，testing peripheral nerve function in patients with type2diabetes，and analyzesits and the correlation of clinical parameters. For diabetes of peripheralneuropathy diagnosis，treatment and prevention to provide the theory basis.Materials and Methods: On the basis of WHO1999，diabetic diagnosticcriteria and typing standard，We selected87patients with type2diabetes whocame to the third medical college of JiLin University from June，2011toJanuary，2012. They were excluded from spiritual or psychological disorders，generally bad form，Cerebrovascular diseases，cervical spondylosis，waist dishoutstanding disease， nerve root stimulation， alcohol， Long-term use ofpainkillers or a sedative，There are other reasons caused by a central orperipheral neuropathy，With physical trauma，the deformity or edema，exceptinfection，fever，obviously high blood pressure，congestive heart failure，pyuriaand hematuria and other reasons can cause microalbuminuria increased. Thethree examinations were examined in the87patients. The patients who haveone abnormal examinational result or above one abnormal examinationalresults are classified in group DPN. They were divided into group DPN (22males，21females)，An average age of (59.07±9.1)years old，The course ofdisease (8.70±7.23) years.and group NDPN(25males，19females)，An averageage of (52.43±12.88)years old，The course of disease (4.60±3.94) years. Theduration，age，body mass index (BMI)，fasting plasma glucose (FPG)，the levels of glycosylated hemoglobin(HbA1c)，microalbuminuria，microalbuminuria/creatinine，C peptide (fasting)，C peptide (2hours)，total cholesterol（TC），triglyeride（TG），high density lipoprotein-cholestero（lHDL-C），low densitylipoprotein-cholesterol （LDL-C），apolipoprotein A1(ApoA1)，apolipoproteinB (ApoB)，bilirubin，VPT were analyzed between the two groups. Data wereanalyzed by SPSS13.0statistic software.Results: the diabetic peripheral neuropathy group and non the diabeticperipheral neuropathy group compared:1.there are evident differences incourse of diease，Age，body mass index，glycated hemoglobin，Cpeptide(2hours)，microalbuminuria，microalbuminuria/creatinine，total bilirubin，indirectbilirubin，VPT difference was statistically significant (P <0.05)；2.In fastingplasma glucose，fasting c-peptide，TG，TC，HDL-c，LDL-C，ApoA1，ApoB，DBIL difference were not statistically significant (P>0.05)；3.Through themultiple linear regression (α＝0.05)，the results for Body mass index，glycatedhemoglobin， microalbuminuria and direct bilirubin， indirect bilirubin asindependent risk factors for DPN (P <0.05).Conclusion:Body mass index, glycated hemoglobin, microalbuminuria anddirect bilirubin, indirect bilirubin as independent risk factors for DPN.Age，duration，C peptide (2hours) as important related factors for DPN. Bloodlipid，C peptide (fasting) was not significantly associated with DPN. Diabetespatients should pay close attention to the risk factors，control the ideal level，reduce the occurrence of peripheral neuropathy.