Study On The Relationship Between Uric Acid, Fibirnogen And Coronary Heatr Disease

Backgrounds:Coronary heart disease is the result of multiple factors, it’s traditionalrisk factors including age, gender smoking, dyslipidemia，Abnormal elevation of the bloodpressure, diabetes and the sugar tolerance exceptionally. However, in clinic，not everypatient with coronary heart disease could be found have the traditional risk factors,in recentyears, more and more new risk factors of coronary heart disease has been found..The studyfind that the abnormalities of UA and fibrinogen in the blood may have played an importantrole in the pathogenesis of CHD.Objections：This article discusses the relationship between serum uric acid andfibrinogen levels and coronary heart disease, the extent of coronary artery stenosis，thestability of atherosclerotic plaque and whether they are the independent risk factors forcoronary heart disease.Method: Chooses the patients in June2009to December2011period of China Japan UnionHospital of Jilin University，according to the results of coronary angiography, all the patientswere divied as coronary heart disease group and control group.160cases as the experimentalgroup, according to the disease is divided into stable angina, unstableangina pectoris andacute myocardial infarction.50cases as the control group which are age-matched and thenormal result ofcoronary angiography, Analysis of the traditional risk factors (hypertension,hyperglycemia, hyperlipidemia, obesity，smoking history, family history) and new riskfactors, uric acid fibrinogen in the two groups change characteristics and clustering. Afterfasting12hours,all the cases were test for lipids, liver function, renal function, ion,,fibrinogen and uric acid. Record the age, sex, height, weight, history of all the samples. According tothe severity of coronary artery stenosis of coronary artery，computing the index calculation（CCS).Use SPSS17.0software package for all data analysis,conduct of T test, chi-squaretest, linear correlation analysis and multiple regression analysis.Results: 1.Compare the coronary heart disease group and control group, uric acid and fibrinogenlevels has significant difference (P <0.05).2. Uric acid levels among the three groups of coronary heart disease group nosignificant statistical difference (P>0.05). Fibrinogen level in unstable angina and acutemyocardial infarction increased significantly.3. In the coronary heart disease group, uric acid levels was no significant differencebetween single, double and multiple lesions; fibrinogen levels in two and three lesions washigher than that in single vessel disease group and there was significant difference.Conclusion:1. Serum uric acid level in the coronary heart disease group was higher than the controlgroup, it can be used as indicators of early prediction of clinical coronary heart disease; butno relationship with the extent of coronary artery stenosis and the stability of atheroscleroticplaque.2. Patients with coronary heart disease, especially in patients with acute myocardialinfarction, fibrinogen levels were significantly increased, it also was an early predictor ofcoronary heart disease, and the increased the degree of fibrinogen associate with thecoronary plaque stability and the extent of coronary artery stenosis.3. The combination of FIB and UA can to determine the severity of disease，fordiagnosis and predict.