The Effect Of Atorvastatin Regimen Continued Sequential Treatment On High Mobility Group Protein And Its Lipids After PCI

Objective To observe the effect of atorvastatin regimen continued sequential treatmenton on peripheral serum of high mobility group protein-1(HMGB-1)、high sensitivity C-reactive protein(hs-CRP) and clinical impact after percutaneous coronary intervention(PCI) in patients with coronary artery disease (CAD).Methods One handrend and one patients with CAD were randomized into three groups:group A、B、C based on the conventional therapy dosage of atorvastatin20mg/d.Group A was given20mg/d prior12hours before PCI. Atorvastatin was not taken on the moment of PCI, After PCI the patients took atorvastatin20mg/d. Group B was given40mg/d prior12hours before PCI, on the moment before PCI, patients were taken atorvastatin40mg/d, after PCI the patients were prescribed atorvastatin20mg/d. Group C was given80mg/d prior12hours before PCI and on the moment of before PCI was taken another40mg of atorvastatin, after PCI the patients took atorvastatin40mg/d. HMGB-1, hs-CRP, TC, TG, LDL-C and HDL-C were measured before, and at48th hours,4th week,12th week and24th week after PCI for follow up.Results The dosage of atorvastatin was positively correlated with LDL-C (P<0.05), but HMGB-1、hs-CRP has nonegitive correlation with TG、HDL and LDL-C (P>0.05). Before admission, at4th12th and24th week after PCI, there were no significant different in three groups among baseline HMGB-1, hs-CRP and48thhour after PCI (P>0.05), and these index in B and C group were lower than those in group A. Atorvastatin40mg/d was significantly reduced HMGB-1, hs-CRP after PCI than it20mg/d did on4th weeks and12th week (P<0.05). The concentration of HMGB-1, hs-CRP were no correlation with lipids (P>0.05). After24weeks of follow-up, B and C group had statistically significant less than group A in cardiovascular events(P<0.05). There was also no difference in group B and C. The levels of TC, TG, HDL, Liver function and renal function did not elevated significantly(P>0.05). The numbers of patients of ALT increased3times than normal in3groups were3,5and7respectively and could recover to normal after4weeks follow up. There were no myalgia, abdominal pain, bloating,constipation, discomfort, headache, skin rashes, dizziness, blurred vision,t aste barrier, muscle pain, fatigue, fever, blood creatine phosphokinase raised phenomenon etal to be found.Conclusion1. Serum inflammatory cytokines like HMGB-1and hs-CRP were elevated after PCI.2. Atorvastatin regimen continued sequential treatment could reduce postoperative inflammation.3. Atorvastatin regimen continued could safely reduce inflammation of Atorvastatin.4. Effect on certain extent anti-inflammatory effects of Atorvastatin.5. Taking40mg/d of atorvastatin regimen for24weeks is safety.