| Objective:To analyze the relationship between the prevalence of impaired fasting glucose (IFG) and its influencing factors in Korean-Chinese and Han nationality of Yanbian rural areas.Methods:1) Using a simple random sampling method,3,217residents aged30-70years, who living in selected rural areas of Yanbian were examined from2007to2009. All subjects knew the informed consent. We excluded ethnic groups other than Korean and Han.2) The data for this study were collected by the family visit, including the general information, past history and family history of cardio cerebral vascular diseases, etc.3) Height, weight, waist circumference, hip circumference and blood pressure was measured by physical examination.4) Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), blood uric acid (UA), gamma-glutamyl transferase (GGT) and fasting insulin (FINS) were measured after12hour fasting.5) Non-normal data was returned by the base-10logarithm and tested. Normal distribution measurement data were analyzed by GLM-General Factorial, the numeration data were tested by the x~2-test; the correlation between FBG and its related factors was analyzed by a simple and the partial correlation analysis; the relationship between the prevalence of impaired fasting glucose (IFG) and its influencing factors were analyzed by multivariate logistic regression analysis, IFG as the dependent variable and age, race, smoking, drinking, education, overall obesity, central obesity, low-HDL-C, high-TG, high-TC, hypertension, GGT, UA, HOMA-IR, HOMA-βand ISI as independent variable were analyzed, and the variables were selected by BACKWARD, selected variables were significant level as a=0.05and deleted variables were significant level as a=0.1.Results:Of3,217subjects,1,732(53.8%) were Korean-Chinese and1,485(46.2%) were Han Chinese. For Korean Chinese,678(39.1%) were males and1,057(60.9%) were females. For Han Chinese,572(38.5%) were males and913(61.5%) were females.1) The prevalence of IFG was increased along with the age, the age distribution of the prevalence of IFG for five10-year.age categories was9.0%for30-39,12.9%for40-49,16.6%for50-59,16.1%for60-69and23.3%for70and older, respectively.2) Compared with the NC, the IFG group had higher mean level of BMI, WC, HDL-C, TG, UA and HOMA-IR, and had lower mean level of HOMA-β and ISI after adjustment for sex, race, age, smoking, drinking and education (P＜0.000).3) According to the quartiles of GGT, UA, HOMA-IR, HOMA-β and ISI, all of subjects were divided into four subgroups and analyzed. Our analysis showed that the prevalence of IFG according to GGT quartiles was11.2%,13.1%,17.3%and18.0%, respectively; UA was11.2%,15.1%,13.3%and19.5%;HOMA-IR were7.2%,11.3%,10.6%and33.2%; HOMA-p cell were24.7%,17.8%,13.5%and4.9%;the ISI were33.2%,10.6%,11.3%and7.2%. The prevalence of IFG was increased along with level of GGT, UA and HOMA-IR, and decreased along with level of HOMA-β and ISI (P<0.001).4) The prevalence of IFG in the group with overall obesity, central obesity, hypertension, high TG and low HDL-C were significantly higher than in normal group, and that was increased along with level of BMI (P<0.001).5) Our partial correlation analysis after adjustment for sex, race, age, smoking, drinking and education showed that there was a positive correlation between FBG and BMI, WC, SBP, DBP, TC, HDL-C, TG, HOMA-IR, UA and GGT, and a negative correlation with HOMA-β and ISI.6) Multivariate logistic regression analysis showed that the prevalence of IFG is closely related with nationality, age, smoking index, overall obesity, central obesity, low HDL-C, high total cholesterol, high TG, GGT, UA, HOMA-IR, HOMA-β and ISI, and dose-response relationship was seen between the prevalence of IFG and age, smoking, BMI, GGT, UA, HOMA-IR, HOMA-β and ISI.Conclusion:(1)The prevalence of IFG is higher in both Korean and Han nationality in this area, and has an increasing trend with age.(2) Compared with the NC, the IFG group had higher mean level of BMI, WC, HDL-C, TG, UA and HOMA-IR, and had lower mean level of HOMA-β and ISI. The prevalence of IFG was increased along with level of GGT, UA and HOMA-IR, and decreased along with level of HOMA-β and ISI.(3) The prevalence of IFG in the group with overall obesity, central obesity, hypertension, high TG and low HDL-C was significantly higher than in normal group, and that was increased along with level of BMI (P<0.001).(4) There was a positive correlation between FBG and BMI, WC, SBP, DBP, TC, HDL-C, TG, HOMA-IR, UA and GGT, and a negative correlation with HOMA-β and ISI.(5) The prevalence of IFG is closely related with nationality, age, smoking index, overall obesity, central obesity, low HDL-C, high total cholesterol, high TG, GGT, UA, HOMA-IR, HOMA-P and ISI, and dose-response relationship was seen between the prevalence of IFG and age, smoking, BMI, GGT, UA, HOMA-IR, HOMA-β and ISI. |
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