Related Research On Concentration Of Copeptin，N-terminal Pro-B-type Natriuretic Peptide, Cardiac Function And Traditional Chinese Medicine Patterns Of Syndrome In Patients With Chronic Heart Failure

objective: To observe the interrelation of content variation ofcopeptin and NT-proBNP of chronic heart failure in different cardiac function,and to explore the clinical meaning. Methods: there were60patients with CHFin hospital, of which male35cases, female25cases, aged31~88years old, theaverage (64.60±13.85) years old,17cases of coronary artery disease,20casesof hypertensive heart disease,10cases of primary myocardial disease,8casesof rheumatic heart disease,3cases of chronic pulmonary heart disease,2caseof congenital heart disease. Cardiac function was distributed the class Ⅰ～Ⅳas NYHA standard. Otherwise, there were20patients as a control groupwithout symptom or sign of CHF which had not any serious disease.1. Chosen60patients with CHF according diagnostic code, discarded noncompliant andincomplete data.2.Observed and recorded general state of health、symptoms、sign and tongue vein syndrome. The CHF patients, as the national clinical studyof Chinese medicine will be the guiding principles, were divided into twogroups:31cases of deficiency of heart-energy group,29cases of heart yangdeficiency group.3.All of patients were taken suction the vein blood withempty stomach in second morning bedside, and detected NT-proBNP、copeptin、blood routine、liver function、kidney function、blood electrolytes、blood glucose, and so on.4.All of patients were examined by UCG within72 hours and checked out LVEF、LVDd.5.Copeptin was measured by ELSIAkit,and the concentration of NT-proBNP was detected by CARDIAC proBNP+detection instrument, and assessed the correlation between copeptin、NT-proBNP and traditional Chinese medicine patterns of syndrome of CHF.6.Data analysis: all of the data were analyzed by statistical package SPSS17.0,the measurement data were expressed with mean±standard deviation (±S), theratio between the two groups were t test, a few groups were compared usinganalysis of variance F test, count data using chi-square test, correlation analysissuing linear correlation analysis. P>0.05, was not statistically significant;p<0.05, was statistical significance; p<0.01, was marked statistical significance.Results:1.CHF group of relevant factors to contrast control group，except forserum creatinine、LVDd、LVEF differences were statistical significance(p<0.05or p<0.01), other factors differences which were sex、age、WBC、ALT、blood glucose、 electrolytes, were not significant (p>0.05).2.NYHAclassification of cardiac function was nearly relationship，CHF group patients’plasma copeptin content were higher than control group, the difference wassignificant(p<0.01), moreover, the level was gradually raised with NYHAclassification，Ⅰ～Ⅱ class group（312.17±63.97）pg/ml, Ⅲ class group（473.86±57.89）pg/ml, Ⅳ级class group（632.31±74.51）pg/ml, were highercontrol group （77.80±14.53） pg/ml, comparison between groups weresignificant(p<0.01).3.Plasma copeptin concentration was closely contact withtraditional Chinese medicine patterns of syndrome, heart qi asthenia group （312.17±63.97）pg/ml，heart yang deficiency group（544.89±102.98）pg/ml，were higher control group（77.80±14.53）pg/ml，comparison between groupswere significant(p<0.01).4. CHF group(3967.60±2211.42) pg/ml was higherthan control group (286.30±81.52) pg/ml,heart yang deficiency group(5687.45±2022.06) pg/ml exceeded deficiency of heart-energy group(2358.71±517.17) pg/ml in plasma NT-proBNP content, moreover， theconcentration was gradually raised with NYHA classification.5.Correlationanalysis:(1) The plasma level of copeptin and NT-proBNP were significantlypositive correlated, r=0.950(p<0.01);(2) The plasma content of copeptin wassignificantly positive correlated with NYHA classification, r=0.904(p<0.01);(3) The plasma level of copeptin and LVDd were positive correlated, r=0.274(p<0.05);(4) The plasma level of copeptin was positive correlation with serumcreatinine, r=0.300(p<0.05)；（5）The plasma level of copeptin was negativecorrelation with LVEF, r=-0.259(p<0.05). Conclusions:1. The concentration ofcopeptin and NT-proBNP were to heighten obviously,which was significantvalue for early diagnosis、assessment of pathogenetic condition and dangerouslayer.2. The copeptin content was close correlation with traditional Chinesemedicine patterns of syndrome, copeptin was to become a susceptible, andoffered objective evidence marker about traditional Chinese medicine patternsof syndrome of CHF.