The Study Of IL-4、IFN-γ Gene Methylation Of Allergic Rhinitis In Uighurs, Han People

Objective: To investigate the difference of IL-4, IFN-γ gene promoter methylationof allergic rhinitis patients and normal control in Uighur, Han people. Methods:Methylation-specific PCR (MSP) detected IL-4, IFN-γ gene methylation of50Uighurscases and50Han cases with allergic rhinitis, and50normal Uighurs and50normal Hancases. Results: The comparison of IL-4gene methylation rate between the Hannationality AR patients with normal control group is statistically significant (P<0.05).The comparison of IL-4gene methylation rate between the Han and Uighur in normalcontrol group is statistically significant (P<0.05). The comparison of IL-4genemethylation rate between the Han and Uighur AR patients is not statistically significant(P>0.05). The comparison of IL-4gene methylation rate between Uighur AR patients andnormal control group is not statistically significant (P>0.05). The comparison of IFN-γgene methylation rate between the Han and Uighur AR patients, between patients withAR and normal controls have no statistical significance (P>0.05). But the comparison ofIFN-γ gene methylation rate between the Han nationality AR patients with normal controlgroup is statistically significant (P<0.05). Conclusion: Artemisia and pigweed are twoimportant aeroallergens of Uighurs and Hans patients with allergic rhinitis. There is nosignificant difference in expression of IL-4gene methylation between the Han andUighur AR patients. The IL-4gene methylation rate of the Han patient with AR is higherthan the normal Han person, which indicates that IL-4gene methylation may play animportant role in the pathogenesis of allergic rhinitis. The IL-4gene hemimethylated ofthe Han nationality group is higher than that of the Uighur nationality group.The IL-4gene methylation in the Han nationality group may tend to the positive expression, theHan population susceptible to allergic rhinitis.There is no significant difference inexpression of IFN-γ gene methylation between the Han and Uighur AR patients. The roleof IFN-γ gene low-methylation in allergic rhinitis needs further research.