Analysis Of Related Risk Factors Of Progressive Cerebral Infarction

Progressive cerebral infarction (Progressive Cerebral Infarction, PCI)is a severe type of cerebral infarction, although after the treatment, thenerve function damage is progressive and stepwise increase until theemergence of severe neurological impairment. Compared with the nonprogressive cerebral infarction, the high morbidity and mortality ofprogressive cerebral infarction, with the poor of conventional treatmentand prognosis has become a hot issue in medical research. The etiology,pathophysiology of progressive cerebral infarction is complex andunclear, and to think that the risk of the patients of cerebral infarctionwith neurological deficit aggravate is related to the patient’s owncondition and some factors of cerebral infarction. This study starts fromthe related risk factors of cerebral infarction, and to analyze the closerelationship between related risk factors and progressive cerebralinfarction, so as to explore the related risk factors and to provide thereference for the early prevention and clinical treatment of progressivecerebral infarction.This study randomly selected370patients of cerebral infarction,with age46-81years, and mean age63±4.43years, and246cases aremale, and124cases are female, who came from the Department of Neurology of China-Japan Union Hospital of Jilin University inSeptember2010to December2012. All the patients of cerebral infarctionwere accorded with the criteria of diagnostic of ischemic stroke, whichwas revised by the fourth national cerebrovascular disease meeting ofChinese Medical Association in1995. On the basis of whetherneurological deficit symptoms to increase after onset of cerebralinfarction,370patients were divided into two groups, patients withneurological deficit aggravated as the progressive group, the other as thenon progressive group. Patients in the progressive group are78cases,with age47-81years, and mean age64±4.31years, and55cases aremale,23cases are female. Patients in the non progressive group are292cases, with age46-79years, and mean age62±4.42years, and191casesare male, and101cases are female. This study shows that progressivecerebral infarction occurred in21.08%,1days after the onset of cerebralinfarction occurred in9cases (11.54%),1-2days for12cases (15.39%),2-3days for29cases (37.18%),3-4days for21cases (26.92%),4-5daysfor5cases (6.41%),5-6days for1case (1.28%),6-7days for1case(1.28%). The two groups were compared with the age, sex, smoking,alcoholism, the degree of nervous functional defect, history ofhypertension, history of diabetes mellitus, history of coronary heartdisease, history of stroke, application of antihypertensive treatment afterthe onset of disease, blood glucose, blood lipid, fibrinogen, fever, the stenosis of intracranial and carotid artery, internal carotid and vertebralbasilar artery steal, cerebral edema, the type of infarction, dehydrationtherapy.SPSS17.0software is applied to process data, the data are processedwith χ~2test or t test, all indicators are analyzed by single factor, as P<0.05has statistical significance, and P<0.01has significant. Results: History ofdiabetes mellitus, the inappropriate application of antihypertensivetreatment after the onset of disease, hyperlipemia, high fibrinogen,internal carotid and vertebral basilar artery steal, brain edema arestatistical significance (P<0.05), and hyperglycemia, fever, the stenosis ofintracranial and carotid artery are statistically significant (P<0.01).Cerebral infarction whether progress as the dependent variable,statistically significant variables as multivariate after single factoranalysis are analyzed by Logistic regression.Conclusion:1、The incidence of cerebral infarction is about21%;2、 History of diabetes mellitus, the excessive application ofantihypertensive treatment after the onset of disease, hyperglycemia,fever, the stenosis of intracranial and carotid artery are closely related riskfactors of progressive cerebral infarction.