The Effect Of Dingxin Granule On High-sensitivity C-reactive Protein For Patients With Paroxysmal Atrial Fibrillation

Objective:To investigate the plasma level of High-sensitivity C-reactive protein (hs-CRP) in patients with paroxysmal atrial fibrillation after the Dingxin Granule treatment and to explore the possible machanism of Dingxin Granule in the prevention or treatment of atrial fibrillation.Methods:Sixty patients with paroxysmal atrial fibrillation were randomly divided into two groups:Dingxin Granule group (n=30) and controll group(n=30). The Dingxin Granule group were administrated with Dingxin Granule and the Controll group were given Amiodarone.The periods were both four week. The plasma levels of hs-CRP in two group were detected with immune turbidimetry respectively (before the treatment, the7th day,the14th day, the21th day and28th day after treatment).Observe the conversion of paroxysmal atrial fibrillation, Andvent-ricular rate controlling and the changes of linical symptoms before and after the treament.Results:1.The hs-CRP levels of the Dingxin Granule group and control group were not statistically different before treatment(P>0.05). The Dingxin Granule group and control group could significantly reduce serum hs-CRP levels of PAF patients, and the Dingxin Granule group reduce serum hs-CRP levels compared with the control group, there was a significant difference between them (P<0.05).2.The hs-CRP levels of non-Cardioversion in the Dingxin Granule group were higher compared with the patients of cardioversion in the Dingxin Granule group(P<0.05).3.After the treatment, The total effect of Dingxin granule group on dioversion was76.67%, and the controll group was80.00%,which showed no significant difference through the Ridit test (P>0.05).4.After the treatment,the average ventricular rate、duration of AF in both group are reduced compared the pretherapy,and there is no difference between the Dingxin Granule group and and the controlled group (P>0.05).5. The patients’ TCM symptoms in the Dingxin granule group are better compared the pretherapy. The rate of improvement in the clinical symptoms of Dingxin granule group reached86.67%and the control group reached53.33%.There was significant difference between the Dingxin Granule group and the control group (P<0.05).Conclusions:1.Dingxin Granule can significantly reduce hs-CRP levels in patients with paroxysmal atrial fibrillation.2.Dingxin Granule can treat PAF,lowing the average ventricular rate、reducing the duration of the PAF and significantly improving the patient’s clinical symptoms.3.The mechanism of Dingxin Granule treatment of PAF may be associated with lowering the hs-CRP levels and inhibiting the inflammatory response, prevent the the ECG reconstruction and atrial structural remodeling, Therefore, Dingxin Granule is an dffective therapy of preventing and treatment of PAF.