Safety Evaluation Of Spiraea Pubescens Turcz

Drinking tea is the Mongolian traditional eating habits, however, the brick tea fluoride content of brewed tea has been known to find the low-fluoride brick tea substitutes become a issue of concern. In recent years, in some areas in Inner Mongolia, Mongolian pastoralists habit of some wild plant stems, leaves, fruit and other parts of the pick on behalf of the brick tea drinking, especially the most common to Spiraea. Studies have found that the meadowsweet plant contains several types of diterpenoid alkaloids. Of traditional Chinese medicine, Mongolian, and Miao medicine Spiraea medicine has long been documented. Spiraea potential toxicity has never been any study of the test to the widely distributed resources most abundant Spiraca in chrysanthemum plants as test materials, its acute toxicity, teratogenicity degeneration security evaluation in order to provide the basis for further development and utilization of meadowsweet plant.During acute toxicity test, no clinical poisoned symptoms and death were observed. All organs no obvious lesions. During the experiment, all mouse were activity, appetite normal, no abnormal defecation, and no other toxic reactions.During subchronic toxicity test,, mouse’ feeding, drinking and fur gloss are normal. Blood parameters were normal on the30th day. An increase of white blood cell count was apperaed in the high dose group of male mice, however,female mice decreased. But the difference was not significant compared with the control group, and the values were within the normal range.Llow-dose group were hemoglobin decreased, however the mice in other groups hemoglobin increased slightly, but compared with control group, these changes are not significant. Each dose groups’ ALT, BUN and creatinine had no significant change. AST values of the middle dose group of male mice increased significantly, but the corresponding dose group in female mice, had no significant changes. All dose group of male and female mice albumin decreased. In addition, triglycerides, glucose, total cholesterol and total protein of each dose group were not significantly increase or decrease. No obvious visceral lesions were observed in the he mice pathology.