Long Term Prognostic Value Of Estrogen Receptor And Progesterone Receptor In Young Patients With Breast Carcinoma

Objective: To investigate the effect of estrogen receptor (ER) andprogesterone receptor (PR) on long term prognostic value in young patientswith breast carcinoma at the southwest of China.Methods: We analysed the data on1866breast cancer female patientswho treated in the First Affiliated Hospital of Chongqing MedicalUniversity between January1994and December2009. ER and PR statusesin370patients with breast carcinoma(younger than35year) wereimmunohistochemical examined and followed up. All statistical analyseswere carried out by using SPSS, version17.0. The Chi-square test was usedto evaluate the differences in the different ER、 PR status. P<0.05considered statistically significant difference. Kaplan-Meier method wasused to calculate the comparison of survival rates between groups andsurvival rates.Results: Totally366out of370patients were followed up for24to288months, with an average of132.64months. ER and PR positive rateswere44.86%（166/370）and38.11%（141/370）respectively. ER and PR statuses were not associated with2-year survival rate and5-year survivalrate. There were significant differences in8-,10-,15-year survival ratebetween ER(+) and ER(-)(χ~2=5.992, P=0.014;χ~2=7.025,P=0.008;χ~2=6.221,P=0.013). Eight-year survival rate in PR(+)was higher than that in PR(-)(χ~2=,9.552,P=0.002);2-year survival rate inER(+)PR(+) was not different from that in ER(-)PR(-)(χ~2=1.963,P=0.161);but5-year and8-year survival rates in ER(+)PR(+) were higher than thosein ER(-)PR(-)(χ~2=7.365,P=0.007; χ~2=5.236,P=0,022).Conclusions: ER and PR are important long term prognostic factors inyoung patients with breast carcinoma. Simultaneous exam of ER and PRis of higher prognostic. ER(-),PR(-) and ER(-)PR(-) indicate poorprognostic, therefore auxiliary treatment including chemotherapy shouldactively be put in force and follow up should be strengthen in order toimprove the prognosis.